Penny A. MacDonald, MD, PhD, FRCPC

macdonaldAssociate Professor of Neurology, Department of Clinical Neurological Sciences and the Brain and Mind Instititue,  Western University
Office: London Health Sciences Centre, University Hospital B10-105
Phone: 519-667-7604
Secretary: Mary Tonelotto


Bio Sketch

Dr. MacDonald received her PhD in cognition at the University of Toronto under the supervision of Dr. Colin MacLeod prior to completing medical school at McMaster University and residency training in Neurology at McGill University. She pursued clinical and research fellowship training in Movement Disorders as a Canadian Institutes of Health, Phase 1 Clinician-Scientist at the Montreal Neurological Institute and the Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal from October 2008- July 2011.



The focus of Dr. MacDonald's research is on understanding the neural bases for cognitive processes with particular interest in defining the unique role of the basal ganglia. A further interest is in understanding the cognitive features of movement disorders such as Parkinson's disease, Lewy Body Dementia, Corticobasal Ganglionic Degeneration, Progressive Supranuclear Palsy, and Multiple Systems atrophy, as well as the effect of medication on cognition in these patient groups. Increasingly, cognitive impairments are recognized in most of these conditions although definitive cognitive profiles have not yet been elaborated. The research combines neuropsychological tests that probe different facets of cognition, with functional neuroimaging techniques in healthy volunteers and patients. The aim is to uncover the neural structures that mediate different cognitive processes and how these processes are impaired in various disease states.

For more information, please visit

Medical Interests

Cognitive Disorders, Movement Disorders

Honours and Awards

  • 2014, Canada Research Chair (Tier 2) in Cognitive Neuroscience and Neuroimaging
  • 2013, "Hot Topics" Designation, World Parkinson Congress
  • 2007, Artur Victor Movement Disorder Travel Award, Montreal Neurological Institute


PubMed Publications Listing


Hiebert NM, Owen AM, Seergobin KN, MacDonald PA. Dorsal striatum mediates deliberate decision making, not late-stage, stimulus-response learning. Hum Brain Mapp. 2017 Sep 25. doi: 10.1002/hbm.23817. [Epub ahead of print] PubMed PMID: 28945307.

Dayal AM, Jenkins ME, Jog MS, Kimpinski K, MacDonald P, Gofton TE. Palliative Care Discussions in Multiple System Atrophy: A Retrospective Review. Can J Neurol Sci. 2017 May;44(3):276-282. doi: 10.1017/cjn.2016.439. Epub 2017 Feb 7. PMID: 28166857

Vo A, Seergobin KN, MacDonald PA. Effects of levodopa on stimulus-response learning versus response selection in healthy young adults.Behav Brain Res. 2017 Jan 15;317:553-561. doi: 10.1016/j.bbr.2016.10.019. Epub 2016 Oct 12. PMID: 27743941