Dr. Schild-Poulter receives CIHR Project Grant

Congratulations to Dr. Caroline Schild-Poulter for being awarded a CIHR Project Grant. She will receive $807,075 over the next 5 years for her research project "Tumour-suppressive regulation of the Wnt/beta-catenin signaling pathway by the CTLH complex."

The Wnt pathway controls the actions of beta-catenin: when this pathway is switched on, beta-catenin functions as a transcription co-factor, activating genes for cell division, migration, and adhesion. When abnormal Wnt/beta-catenin signalling occurs, then cancer often results. The CTLH complex in mammals comprises 7 subunits of which one of them, RanBPM, has been linked to the control of cancer and of beta-catenin signalling within cells.

Dr. Schild-Poulter and her research team plan to investigate the mechanism by which beta-catenin is influenced by the CTLH complex and what happens to tumour development when the CTLH complex no longer functions. Their findings will illuminate ways to block signalling pathways leading to cancer, and such discoveries hold promise for the development of cancer therapeutics.