Schulich school of Medicine and Dentistry logo Department of Anatomy and Cell Biology Schulich School of Medicine & Dentistry

Dr. Sarah McLean


Assistant Professor
(Joint Appointment with Physiology and Pharmacology)

PH.D. Western University

Office:  Medical Sciences Building, Room 203
Phone: (519) 661-2111 ext .88587
Fax: (519) 661-3827

Research Interests:

Dr. Sarah McLean received her undergraduate degree from the University of Waterloo and her Doctorate from Western. Dr. McLean began her career at Western in the laboratory of Dr. John Di Guglielmo, where she worked on signalling pathways involved in non-small cell lung cancer. Dr. McLean is thrilled to be pursuing her passion for teaching and educational scholarship in the BMSUE program. Dr. McLean’s teaching began at the University of Waterloo and expanded for both small and large group teaching while at Western, incorporating novel web-based applications including Twitter, as well as animations, video and study guides. Dr. McLean's primary responsibilities are the management, teaching and development of advanced level interdisciplinary medical sciences courses. Developed courses will be incorporated into the Honors Specialization in Interdisciplinary Medical Sciences (IMS) module, which represents 40% of the student enrolment in the BMSc Program. An enthusiastic and innovative educator, Dr. McLean will also be an e-learning resource person to the basic medical science departments for the use of online and e-learning methodologies in undergraduate courses.

Selected Publications:

  1. Sarah McLean, Moshmi Bhattacharya, Gianni M. Di Guglielmo. arrestin2 interacts with TRII to regulate Smad-dependent and Smad-independent signal transduction. Cell. Signal. (2012). doi: 10.1016/j.cellsig.2012.10.001

  2. Sarah McLean, Gianni M. Di Guglielmo. TGF(transforming growth factor ) receptor type III directs clathrin-mediated endocytosis of TGFreceptor types I and II. Biochem. J. (2010). 429: 137-145.

  3. Valbona Luga, Sarah McLean, Christine Le Roy, Maureen O’Connor-McCourt, Jeff L Wrana, Gianni M Di Guglielmo. The extracellular domain of the TGFβ type II receptor regulates membrane raft partitioning. Biochem. J. (2009) 421: 119-131.

  4. Anita Woods*, Daphne Pala*, Laura Kennedy, Sarah McLean, Jason Rockel, Guoyan Wang, Andrew Leask, Frank Beier. Osteoarthritis Cartilage (2009) 3: 406-413.

  5. Shaoqiong Chen, Sarah McLean, David E. Carter, Andrew Leask. The gene expression profile induced by Wnt 3a in NIH 3T3 fibroblasts. J. Cell Commun. Signal. (2007) 1: 175-183.