Dr. Patrick Lajoie

Patrick LajoieAssistant Professor

PDF  Albert Einstein College of Medicine
Ph.D.
 University of British Columbia
B.Sc. Université du Québec à Montréal
Office: Medical Sciences Building 438
Phone: 519-661-2111 Ext 88220
Fax: 519-661-3936
Email: plajoie3@uwo.ca
Visit: www.lajoielab.com

Research Interests:

Our lab is studying the mechanisms regulating secretory protein homeostasis under both normal and pathological conditions. We focus on understanding how the quality control machinery of the endoplasmic reticulum (ER) promotes efficient protein folding under various conditions. Proper folding and quality control of secretory proteins are crucial to cell viability. Accumulation of misfolded proteins can lead to loss of protein function and cell death. Cells activate the unfolded protein response (UPR) to cope with misfolded protein accumulation in the ER, but excessive UPR can trigger apoptosis. UPR activation has been associated with various diseases such as diabetes, Huntington’s disease and cardiac dysfunction. We employ mammalian tissue culture models, yeast genetics, molecular biology, quantitative live cell imaging techniques and high-throughput RNA-SEQ to understand how cells detect, respond and cope with misfolded proteins.

Current research interests include:

  • The role of the UPR in Huntington’s disease
  • Interplay between UPR and ribosome biogenesis
  • Fitness of the secretory pathway in yeast aging

Publications: 

For publications, please visit Dr. Lajoie's Google Scholar page or Pub Med page.