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2015 Publications

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2014 Publications

    1. Phelan CM, Iqbal J, Lynch HT, Lubinski J, Gronwald J, Moller P, Ghadirian P, Foulkes WD, Armel S, Eisen A, Neuhausen SL, Senter L, Singer CF, Ainsworth P, Kim-Sing C, Tung N, Llacuachaqui M, Chornokur G, Ping S, Narod SA, Hereditary Breast Cancer Study Group. Incidence of colorectal cancer in BRCA1 and BRCA2 mutation carriers: results from a follow-up study. Br J Cancer. 2014 Jan 21;110(2):530-4.530-4 doi:10.1038/bjc.2013.741. PMID24292448
    2. Kotsopoulos J, Lubinski J, Moller P, Lynch HT, Singer CF, Eng C, Neuhausen SL, Karlan B, Kim-Sing C, Huzarski T, Gronwald J, McCuaig J, Senter L, Tung N, Ghadirian P, Eisen A, Gilchrist D, Blum JL, Zakalik D, Pal T, Sun P, Narod SA, Hereditary Breast Cancer Clinical Study Group (Ainsworth P, et al). Timing of oral contraceptive use and the risk of breast cancer in BRCA1 mutation carriers. Breast Cancer Res Treat579-86 doi:10.1007/s10549-013-2. PMID24458845
    3. Finch AP, Lubinski J, Møller P, Singer CF, Karlan B, Senter L, Rosen B, Maehle L, Ghadirian P, Cybulski C, Huzarski T, Eisen A, Foulkes WD, Kim-Sing C, Ainsworth P, Tung N, Lynch HT, Neuhausen S, Metcalfe KA, Thompson I, Murphy J, Sun P, Narod SA. Impact of Oophorectomy on Cancer Incidence and Mortality in Women With a BRCA1 or BRCA2 Mutation. J Clin Oncol1547-53 doi:10.1200/JCO.2013.53.  PMID24567435
    4. Kertesz A, Finger E, Murrell J, Chertkow H, Ang LC, Baker M, Ravenscroft T, Rademakers R, Munoz DG. Progressive Supranuclear Palsy in a family with TDP-43 pathology. Neurocase doi:10.1080/13554794.201. PMID24479957
    5. Tong J, Fitzmaurice P, Furukawa Y, Schmunk GA, Wickham DJ, Ang LC, Sherwin A, McCluskey T, Boileau I, Kish SJ. Is brain gliosis a characteristic of chronic methamphetamine use in the human? Neurobiol Dis 107-18 doi:10.1016/j.nbd.2014.0. PMID24704312
    6. Lin AW, Das S, Fraser JA, Ang LC, Florendo-Cumbermack A, Jenkins ME, Tay KY. Emergence of Primary CNS Lymphoma in a Patient with Findings of CLIPPERS. Can J Neurol Sci. 2014 Jul;41(4):528-9.528-9.  PMID24878484
    7. Xiao J, Li J, Cai L, Chakrabarti S, Li X. Cytokines and diabetes research. Journal of Diabetes Research, Volume 2014, 2014, Article number 920613 PMID24551859
    8. Mortuza R, ChakrabartiS. Glucose-induced cell signaling in the pathogenesis of diabetic cardiomyopathy. Heart Fail Rev, 75-86 doi:10.1007/s10741-013-9. PMID23430126
    9. Chen S, Puthanveetil P, Feng B, Matkovich SJ, Dorn GW, Chakrabarti S. Cardiac miR-133a overexpression prevents early cardiac fibrosis in diabetes. Journal of Cellular and Molecular MedicineVolume 18, Issue 3, March 2014, Pages 415-421. PMID24428157
    10. Feng B, Cao Y, Chen S, Ruiz M, Chakrabarti S. miRNA-1 regulates endothelin-1 in diabetes. Life Sci2014 Mar 7;98(1):18-23, doi:10.1016/j.lfs.2013.12.199. Epub 2014 Jan 3.  PMID24394957
    11. Cong W, Zhao T, Zhu Z, Huang B, Ma W, Wang Y, Tan Y, Chakrabarti S, Li X, Jin L, Cai L. Metallothionein prevents cardiac pathological changes in diabetes by modulating nitration and inactivation of cardiac ATP synthase. J Nutr Biochem 463-74, doi:10.1016/j.jnutbio.20. PMID24629910
    12. Beaton MD, Chakrabarti S, Adams PC. Inflammation is not the cause of an elevated serum ferritin in non-alcoholic fatty liver disease. Ann Hepatol353-6. PMID24756010
    13. Mortuza R, Feng B, Chakrabarti S. miR-195 regulates SIRT1-mediated changes in diabetic retinopathy. Diabetologia1037-46, doi:10.1007/s00125-014-3. PMID24570140.
    14. Zhao YZ, Tian XQ, Zhang M, Cai L, Ru A, Shen XT, Jiang X, Jin RR, Zheng L, Hawkins K, Chakrabarti S, Li XK, Lin Q, Yu WZ, Ge S, Lu CT, Wong HL. Functional and pathological improvements of the hearts in diabetes model by the combined therapy of bFGF-loaded nanoparticles with ultrasound-targeted microbubble destruction. J Control Release. 2014 Jul 28;186:22-31. doi:10.1016/j.jconrel.2014.04.054. Epub 2014 May 9. PMID24815422.
    15. Cao Y, Feng B, Chen S, Chu Y, Chakrabarti S. Mechanisms of endothelial to mesenchymal transition in the retina in diabetes. Investigative Ophthalmology Visual ScienceInvest Ophthalmol Vis Sci. 2014 Oct 21;55(11):7321-31. doi:10.1167/iovs.14-15167. PMID25335984.
    16. Zuo Y, Wu Y, Wehrli B, Chakrabarti S, Chakraborty C. Modulation of ERK5 Is a novel mechanism by which CDc42 Regulates Migration of Breast Cancer Cells. Journal Cell Biochemistry. doi:10.1002/jcb.24950. 
    17. Puthanveetil P, Thomas AA, Chakrabarti S. microRNAs in diabetes - are they perpetrators in disguise or just epiphenomena? Non-coding RNAs in Endocrinology. Volume 1, Issue 1, ISSN (Online) 2300-4258. doi:10.2478/micrnado-2014-0002, September 2014.
    18. Beaucage KL, Xiao A, Pollmann SI, Grol MW, Holdsworth DW, Sims SM, Darling MR, Dixon SJ. Loss of P2X7 nucleotide receptor function leads to abnormal fat distribution in mice. Purinergic Signalling 2014 Jun;10(2):291-304. doi:10.1007/s11302-013-9388-x. Epub 2013 Nov 13.  PMID24222214.
    19. Poon R, Su N, Ching V, Darling M, Grushka M. Reduction in unstimulated salivary flow rate in burning mouth syndrome. Br Dent J. 2014 Oct 10;217(7):E14. doi:10.1038/sj.bdj.2014.884. PMID25303607.
    20. Castonguay MC, Li-Chang HH, Driman DK. Venous invasion in oesophageal adenocarcinoma: enhanced detection using elastic stain and association with adverse histological features and clinical outcomes. Histopathology 693-700, doi:10.1111/his.12308. PMID24117900.
    21. Osmond A, Li-Chang H, Kirsch R, Divaris D, Falck V, Liu DF, Marginean C, Newell K, Parfitt J, Rudrick B, Sapp H, Smith S, Walsh J, Wasty F, Driman DK. Interobserver variability in assessing dysplasia and architecture in colorectal adenomas: a multicentre Canadian study. J Clin Pathol, doi:10.1136/jclinpath-20. PMID25004943.
    22. Rajakumar C, Vilos GA, Vilos AG, Marks JL, Ettler HC, Pautler SS. Combined Transurethral and Laparoscopic Partial Cystectomy and Robotically Assisted Bladder Repair for the Treatment of Bladder Endocervicosis: Case Report and Review of the Literature. J Obstet Gynaecol Can141-145. PMID24518913.
    23. Girgis H, Masui O, White NM, Scorilas A, Rotondo F, Seivwright A, Gabril M, Filter ER, Girgis AH, Bjarnason GA, Jewett MA, Evans A, Al-Haddad S, Siu KM, Yousef GM. Lactate Dehydrogenase A is a potential prognostic marker in clear cell renal cell carcinoma. Mol Cancer101 doi:10.1186/1476-4598-13. PMID24885701.
    24. Canadian Association of Pathologists Telepathology Guidelines Committee, Bernard C, Chandrakanth SA, Cornell IS, Dalton J, Evans A, Garcia BM, Godin C, Godlewski M, Jansen GH, Kabani A, Louahlia S, Manning L, Maung R, Moore L, Philley J, Slatnik J, Srigley J, Thibault A, Picard DD, Cracower H, Tetu B. Guidelines from the Canadian Association of Pathologists for establishing a telepathology service for anatomic pathology using whole-slide imaging. J Pathol Inform15, doi:10.4103/2153-3539.129455. eCollection 2014. PMID24843826.
    25. Wang H, Zhang Z, Tian W, Liu T, Han H, Fu Q, Garcia B, Li X. Memory T Cells Mediate Cardiac Allograft Vasculopathy and are Inactivated by Anti-OX40L Monoclonal Antibody. Cardiovasc Drugs Ther.2014; 28: 115-22. doi:10.1007/s10557-013-6502-9. PMID24254032.
    26. Palmer TD, Martínez CH, Vasquez C, Hebron KE, Jones-Paris C, Arnold SA, Chan SM, Chalasani V, Gomez-Lemus JA, Williams AK, Chin JL, Giannico GA, Ketova T, Lewis JD, Zijlstra A. Integrin-free tetraspanin CD151 can inhibit tumor cell motility upon clustering and is a clinical indicator of prostate cancer progression. Cancer Res173-87 doi:10.1158/0008-5472.CA. PMID24220242.
    27. Lau A, Khan K, Pavlosky A, Yin Z, Huang X, Haig A, Liu W, Singh B, Zhang ZX, Jevnikar AM. Serine Protease Inhibitor-6 Inhibits Granzyme B-Mediated Injury of Renal Tubular Cells and Promotes Renal Allograft Survival. Transplantation doi:10.1097/TP.000000000. PMID24918613.
    28. Lau A, Wang S, Liu W, Haig A, Zhang ZX, Jevnikar AM. Glycyrrhizic Acid Ameliorates HMGB1-Mediated Cell Death and Inflammation after Renal Ischemia Reperfusion Injury. Am J Nephrol84-95 doi:10.1159/000364908. PMID25059568.
    29. Rizek P, Cheung C, McLachlan RS, Hayman-Abello B, Lee DH, Hammond RR, Mirsattari SM. Childhood-onset nonprogressive chronic encephalitis. Epilepsy Behav. 2014 Feb;31:85-90 doi:10.1016/j.yebeh.2013. PMID24368410.
    30. Haust, MD, Gilber-Barness EF.  Founders of Pediatric Pathology: Remembering Dr Marie Valdes-Dapena.  Pediatric and Developmental Pathology 17, 165-168, 2014 doi: 10.2350/14-02-1442-PB.1
    31. Weinreb I, Piscuoglio S, Martelotto LG, Waggott D, Ng CK, Perez-Ordonez B, Harding NJ, Alfaro J, Chu KC, Viale A, Fusco N, da Cruz Paula A, Marchio C, Sakr RA, Lim R, Thompson LD, Chiosea SI, Seethala RR, Skalova A, Stelow EB, Fonseca I, Assaad A, How C, Wang J, de Borja R, Chan-Seng-Yue M, Howlett CJ, Nichols AC, Wen YH, Katabi N, Buchner N, Mullen L, Kislinger T, Wouters BG, Liu FF, Norton L, McPherson JD, Rubin BP, Clarke BA, Weigelt B, Boutros PC, Reis-Filho JS. Hotspot activating PRKD1 somatic mutations in polymorphous low-grade adenocarcinomas of the salivary glands. Nat Genet. 2014 Nov;46(11):1166-9 doi:10.1038/ng.3096. PMID25240283.
    32. Wong H, Watt C, Elsayed S, John M, Johnson G, Katz K, Krajden S, Lee C, Mazzulli T, Ostrowska K, Richardson D, Toye B, Vermeiren C, Yamamura D, and Simor AE. Characterization of Methicillin-Resistant Staphylococcus aureus Isolates From Patients with Persistent or Recurrent Bacteremia. Canadian Journal of Infectious Diseases & Medical MicrobiologyMarch/April 2014, Volume 25, Issue 2: 83-86.
    33. Lutz K, Hayward V, Joseph M, Wong E, Temple-Oberle C. Current biopsy practices for suspected melanomas: A Survey of Family Physicians in Southwestern Ontario. The Canadian Journal of Plastic Surgery, 22(3), 175-178.
    34. Kum JJY, Khan ZA. Propranolol inhibits growth of hemangioma-initiating cells but does not induce apoptosis. Pediatr Res75: 381-388, 2014 doi:10.1038/pr.2013.231. Epub 2013 Dec 2. PMID24296797.
    35. Keats EC, Dominguez JM, Grant MB, Khan ZA. Switch from canonical to noncanonical Wnt signaling mediates high glucose-induced adipogenesis. Stem Cells32: 1649–1660, 2014 doi: 10.1002/stem.1659.  PMID24496952.
    36. Piccinin MA, Khan ZA. Pathophysiological role of enhanced bone marrow adipogenesis in diabetic complications. Adipocyte 3; 14-23, 2014 doi:10.4161/adip.32215.
    37. Cutz JC1, Craddock KJ, Torlakovic E, Brandao G, Carter RF, Bigras G, Deschenes J, Izevbaye I, Xu Z, Greer W, Yatabe Y, Ionescu D, Karsan A, Jung S, Fraser RS, Blumenkrantz M, Lavoie J, Fortin F, Bojarski A, Côté GB, van den Berghe JA, Rashid-Kolvear F, Trotter M, Sekhon HS, Albadine R, Tran-Thanh D, Gorska I, Knoll JH, Xu J, Blencowe B, Iafrate AJ, Hwang DM, Pintilie M, Gaspo R, Couture C, Tsao MS. Canadian Anaplastic Lymphoma Kinase Study: A Model for multicenter standardization and optimization of ALK testing in lung cancer. J Thoracic Oncology 9(9):1255-1263 doi:10.1097/JTO.0000000000000239  PMID25122422.
    38. Rogan PK, Li Y, Wickramasinghe A, Subasinghe A, Caminsky N, Khan W, Samarabandu J, Wilkins R, Flegal F, Knoll JH. Automating dicentric chromosome detection from cytogenetic biodosimetry data. Radiat Prot Dosimetry2014 Jun;159(1-4):95-104 doi:10.1093/rpd/ncu133. Epub 2014 Apr 21. PMID24757176.
    39. Owrangi AM, Lannigan R, Simonovic SP. Interaction between land-use change, flooding and human health in Metro Vancouver, Canada. Natural Hazards, Volume 72, Issue 2, June 2014, Pages 1219-1230
    40. Cancer Genome Atlas Research Network (affiliated with Ontario Tumour Bank: Bartlett JMS, Kodeeswara S, Parfitt J, Sekhon H, Albert M). Comprehensive molecular profiling of lung adenocarcinoma. Nature543-50 doi:10.1038/nature13385. PMID25079552.
    41. Sy K, Parfitt J, Marginean C, Riddell RH, Streutker CJ. Inflammatory pseudotumours of the esophagus. Histopathology. 2014 Nov 13. doi:10.1111/his.12615. [Epub ahead of print]. PMID25393329.
    42. Farhan SM, Wang J, Robinson JF, Lahiry P, Siu VM, Prasad C, Kronick JB, Ramsay DA, Rupar CA, Hegele RA. Exome sequencing identifies NFS1 deficiency in a novel Fe-S cluster disease, infantile mitochondrial complex II/III deficiency. Mol Genet Genomic Med 73-80 doi:10.1002/mgg3.46. PMID24498631.
    43. Prasad M, Narayan B, Prasad AN, Rupar CA, Levin S, Kronick J, Ramsay D, Tay KY, Prasad C. MELAS: A Multigenerational Impact of the MTTL1 A3243G MELAS Mutation. Can J Neurol Sci. 2014 Mar;41(2):210-9. PMID24534033.
    44. Cohen MC, Ramsay DA. "Shaken baby syndrome" and forensic pathology. Forensic Sci Med Pathol244-5 doi:10.1007/s12024-013-9. PMID24464795.
    45. Sangle NA, Schmidt RL, Patel JL, Jeffrey Medeiros L, Agarwal AM, Perkins SL, Salama ME. Optimized immunohistochemical panel to differentiate myeloid sarcoma from blastic plasmacytoid dendritic cell neoplasm. Mod Pathol.2014 Aug;27(8):1137-43. doi:10.1038/modpathol.2013.238. Epub 2014 Jan 3. PMID24390220.
    46. Layfield LJ, Schmidt RL, Sangle N, Crim JR. Diagnostic accuracy and clinical utility of biopsy in musculoskeletal lesions: a comparison of fine-needle aspiration, core, and open biopsy techniques. Diagn Cytopathol 2014 Jun;42(6):476-86. doi:10.1002/dc.23005. Epub 2014 Mar 19. PMID24644128.
    47. Jacques R, Kogon S, Shkrum M. An experimental model of tool mark striations by a serrated blade in human soft tissues. Am J Forensic Med Pathol59-61 doi:10.1097/PAF.00000000. PMID24457587.
    48. Bramwell VH, Tuck AB, Chapman JA, Anborgh PH, Postenka CO, Al-Katib W, Shepherd LE, Han L, Wilson CF, Pritchard KI, Pollak MN, Chambers AF. Assessment of osteopontin in early breast cancer: correlative study in a randomised clinical trial. Breast Cancer ResR8 doi:10.1186/bcr3600. PMID24451146.
    49. Fok TC, Lapointe H, Tuck AB, Chambers AF, Jackson-Boeters L, Daley TD, Darling MR. Expression and localization of osteopontin, homing cell adhesion molecule/CD44, and integrin αvβ3 in mucoepidermoid carcinoma and acinic cell adenocarcinoma of salivary gland origin. Oral Surg Oral Med Oral Pathol Oral Radiol 320-9 doi:10.1016/j.oooo.2014. PMID25151586.
    50. MacMillan CD, Leong HS, Dales DW, Robertson AE, Lewis JD, Chambers AF, Tuck AB. Stage of breast cancer progression influences cellular response to activation of the WNT/planar cell polarity pathway. Sci Rep6315 doi:10.1038/srep06315. PMID25204426.
    51. Lalani N, Paszat L, Sutradhar R, Thiruchelvam D, Nofech-Mozes S, Hanna W, Slodkowska E, Done SJ, Miller N, Youngson B, Tuck A, Sengupta S, Elavathil L, Chang MC, Jani PA, Bonin M, Rakovitch E. Long-term Outcomes of Hypofractionation Versus Conventional Radiation Therapy After Breast-Conserving Surgery for Ductal Carcinoma In Situ of the Breast. Int J Radiat Oncol Biol Phys doi:10.1016/j.ijrobp.201. PMID25220719.
    52. MacMillan CD, Leong HS, Dales DW, Robertson AE, Lewis JD, Chambers AF, Tuck AB. Stage of Breast Cancer Progression Influences Cellular Response to Activation of the WNT/Planar Cell Polarity Pathway. Scientific Reports, 4 : 6315 doi:10.1038/srep06315.
    53. O'Connor K, Walsh JC, Schaeffer DF.Combined hepatocellular-cholangiocarcinoma (cHCC-CC): a distinct entity. Ann Hepatol. 2014 May-Jun;13(3):317-22. PMID24756005.
    54. Dowthwaite S, Szeto C, Wehrli B, Daley T, Whelan F, Franklin J, Nichols A, Yoo J, Fung K. Contact endoscopy as a novel technique in the detection and diagnosis of oral cavity and oropharyngeal mucosal lesions in the head and neck. J Laryngol Otol1-6 doi:10.1017/S00222151130. PMID24460932.
    55. Zuo Y, Wu Y, Wehrli B, Chakrabarti S, Chakraborty C. Modulation of ERK5 Is a Novel Mechanism by Which Cdc42 Regulates Migration of Breast Cancer Cells. J Cell Biochem doi:10.1002/jcb.24950. PMID25160664.
    56. Yeh DH, Wong J, Hoffbauer S, Wehrli B, Sommer D, Rotenberg BW. The utility of routine polyp histopathology after endoscopic sinus surgery. Int Forum Allergy Rhinol doi:10.1002/alr.21378.  PMID25142311.
    57. Zhang X, Liu Y, Zhang G, Shi J, Zhang X, Zheng X, Jiang AT, Zhang ZX, Johnston N, Siu KS, Chen R, Lian D, Koos D, Quan D, Min WP. Synergic silencing of costimulatory molecules prevents cardiac allograft rejection. J Transl Med. 2014 May 22;12:142. doi: 10.1186/1479-5876-12-142.
    58. Chen D, Koropatnick J, Jiang N, Zheng X, Zhang X, Wang H, Yuan K,Siu KS, Shunnar A, Way C, Min WP. Targeted siRNA Silencing of Indoleamine 2, 3-Dioxygenase in Antigen-presenting Cells Using Mannose-conjugated Liposomes: A Novel Strategy for Treatment of Melanoma. J Immunother. 2014 Feb-Mar;37(2):123-34.
    59. Siu KS, Chen D, Zheng X, Zhang X, Johnston N, Liu Y, Yuan K, Koropatnick J, Gillies ER, Min WP. Non-covalently functionalized single-walled carbon nanotube for topical siRNA delivery into melanoma. Biomaterials 2014 Mar;35(10):3435-42.
    60. Chen K, Ablimit A, Ling F, Wu W, Shan W, Qin W, Keweier T, Zuo H, Zhang F, Ma Z, Zheng X. Paternal and maternal genetic analysis of a desert Keriyan population: Keriyans are not the descendants of Guge Tibetans. PLoS One. 2014 Jun 26;9(6):e100479.
    61. Shan W, Ablimit A, Zhou W, Zhang F, Ma Z, Zheng X. Genetic polymorphism of 17 Y chromosomal STRs in Kazakh and Uighur populations from Xinjiang, China. Int J Legal Med. 2014 Jan 8. [Epub ahead ofprint].
    62. Maleki Vareki S, Rytelewski M, Figueredo R, Chen D, Ferguson PJ, Vincent M, Min W, Zheng X, Koropatnick J. Indoleamine 2,3-dioxygenase mediates immune-independent human tumor cell resistance to olaparib, gamma radiation,and cisplatin. Oncotarget. 2014 May 15;5(9):2778-91