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2014

Kasper, K. J., J. J. Zeppa, A. T. Wakabayashi, S. X. Xu, D. M. Mazzuca, I. Welch, M. L. Baroja, M. Kotb, E. Cairns, P. P. Cleary, S. M. M. Haeryfar and J. K. McCormick. Bacterial superantigens promote acute nasopharyngeal infection by Streptococcus pyogenes in a human MHC class II-dependent manner. PLoS Pathogens.

S-D Ha, CY Han, C Reid, SO Kim. "HDAC8-mediated epigenetic reprogramming plays a key role in resistance to anthrax lethal toxin-induced pyroptosis in macrophages". Journal of Immunology, In press.

Rytelewski M, Tong J, Buensuceso A, Leong HS, Maleki Vareki S, Figueredo R, Di Cresce C, Wu SY, Herbrich S, Baggery KA, Romanow L, Shepherd T, Deroo BJ, Sood AK, Chambers AF, Vincent M, Ferguson PJ, Koropatnick J. BRCA2 inhibition enhances cisplatin-mediated alterations in tumor cell proliferation, metabolism, and metastasis. Molecular Oncology. In press [May 2014]

Maleki Vareki S, Rytelewski M, Figueredo R, Chen D, Ferguson PJ, Vincent M, Min W, Zheng X, Koropatnick J. Indoleamine 2,3-dioxygenase mediates immune-independent human tumor cell resistance to olaparib, gamma radiation, and cisplatin. Oncotarget. 2014 Apr 18. [Epub ahead of print] Control of Established Colon Cancer Xenografts Using a Novel Humanized Single Chain Antibody-Streptococcal Superantigen Fusion Protein Targeting the 5T4 Oncofetal Antigen. Patterson KG, Dixon Pittaro JL, Bastedo PS, Hess DA, Haeryfar SM, McCormick JK. PLoS One. 2014 Apr 15;9(4):e95200. doi: 10.1371/journal.pone.0095200. eCollection 2014. PMID: 24736661

A robust scoring system to evaluate sepsis severity in an animal model. Shrum B, Anantha RV, Xu SX, Donnelly M, Haeryfar SM, McCormick JK, Mele T. BMC Res Notes. 2014 Apr 12;7(1):233

Identification and characterization of multiple conserved nuclear localization signals within adenovirus E1A. Marshall KS, Cohen MJ, Fonseca GJ, Todorovic B, King CR, Yousef AF, Zhang Z, Mymryk JS. Virology. 2014 Apr;454-455C:206-214. doi: 10.1016/j.virol.2014.02.020. Epub 2014 Mar 13.

Interferon-induced HERC5 is evolving under positive selection and inhibits HIV-1 particle production by a novel mechanism targeting Rev/RRE-dependent RNA nuclear export. Woods MW, Tong JG, Tom SK, Szabo PA, Cavanagh CP, Dikeakos JD, Haeryfar SMM, Barr SD. Retrovirology.2014, 11:27. DOI: 10.1186/1742-4690-11-27.

TCA cycle activity in Staphylococcus aureus is essential for iron-regulated synthesis of staphyloferrin A, but not staphyloferrin B: the benefit of a second citrate synthase. Sheldon JR, Marolda CL, Heinrichs DE. Mol Microbiol. 2014 Mar 26. doi: 10.1111/mmi.12593. [Epub ahead of print]

Bacterial microbiota of human breast tissue. Camilla Urbaniak, Joanne Cummins, Muriel Brackstone, Jean M. Macklaim, Gregory B. Gloor, Chwanrow K. Baban, Leslie Scott, Deidre M. O’Hanlon, Jeremy P.Burton, Kevin P. Francis, Mark Tangney, Gregor Reid. AEM Accepts, published online ahead of print on 7 March 2014 Appl. Environ. Microbiol. doi:10.1128/AEM.00242-14

Singh B. 2014. Prevention of type 1 diabetes and its recurrence by immunotherapy with Mycobacterial adjuvants in "The Value of BCG and TNF in Autoimmunity", Ed. Faustman DL Publisher: Elsevier Chapter 2, pp27-36.

PU.1 promotes cell cycle exit in the murine myeloid lineage associated with downregulation of E2F1. Rachel Ziliotto, Marek R. Gruca, Shreya Podder, Greg Noel, Cora K. Ogle, David A. Hess, and Rodney P. DeKoter. Experimental Hematology 2014;42:204–217

The human papillomavirus E7 proteins associate with and alter p190RhoGAP function. Biljana Todorovic, Anthony C. Nichols, Jennifer M. Chitilian, Michael P. Myers, Trevor G. Shepherd, Sarah J. Parsons, John W. Barrett, Lawrence Banks, Joe S. Mymryk. Published ahead of print 8 January 2014, doi: 10.1128/JVI.03263-13

Negative regulation of the peptidylarginine deiminase type IV promoter by NF-κB in human myeloid cells. Abbas AK, Le K, Pimmett VL, Bell DA, Cairns E, Dekoter RP. Gene. 2014 Jan 1;533(1):123-31. doi: 10.1016/j.gene.2013.09.108. Epub 2013 Oct 16.

Antihomocitrullinated Fibrinogen Antibodies are Specific to Rheumatoid Arthritis and Frequently Bind Citrullinated Proteins/peptides. Scinocca M, Bell DA, Racapé M, Joseph R, Shaw G, McCormick JK, Gladman DD, Pope J, Barra L, Cairns E. J Rheumatol. 2014 Jan 15. [Epub ahead of print]

Serum Cytokine Profile of Unaffected First-degree Relatives of Patients with Rheumatoid Arthritis. Barra L, Summers K, Bell D, Cairns E. J Rheumatol. 2014 Jan 15. [Epub ahead of print]

Villanueva AI, Haeryfar SM, Mallard BA, Kulkarni RR, Sharif S: Functions of invariant natural killer T cells are modulated by Toll-like receptor ligands and interferon-alpha. Innate Immunity 2014

Vasostatin-1 antigenic epitope mapping for induction of cellular and humoral immune responses to chromogranin A autoantigen in NOD mice Enayat Nikoopour, Rebecca Cheung, Stacey Bellemore, Olga Krougly, Edwin Lee-Chan, Mats Stridsberg, Bhagirath Singh. Eur. J. Immunol. 2014; 44: (in press). Accepted manuscript online: 14 Jan. 2014; DOI: 10.1002/eji.201343986

Probiotics, prebiotics, and the host microbiome: the science of translation. Bryon Petschow1 Joel Dor´ e, Patricia Hibberd Timothy Dinan, Gregor Reid, Martin Blaser, Patrice D. Cani, Fred H. Degnan, Jane Foster, Glenn Gibson, John Hutton, Todd R. Klaenhammer, Ruth Ley, Max Nieuwdorp, Bruno Pot, David Relman, Andrew Serazin, and Mary Ellen Sanders. Ann. N.Y. Acad. Sci. ISSN 0077-8923

Crystal and Solution Structure Analysis of FhuD2 from Staphylococcus aureus in Multiple Unliganded Conformations and Bound to Ferrioxamine-B. Podkowa KJ, Briere LA, Heinrichs DE, Shilton BH. Biochemistry. 2014 Mar 8. [Epub ahead of print]

Adenovirus E1A recruits the hPaf1 complex to enhance transcriptional elongation. Gregory J. Fonseca, Michael J. Cohen and Joe S. Mymryk. Published ahead of print 5 March 2014, doi: 10.1128/JVI.03518-13 JVI.03518-13

Growth promotion of the opportunistic human pathogen, Staphylococcus lugdunensis, by heme, hemoglobin, and coculture with Staphylococcus aureus. Brozyna JR, Sheldon JR, Heinrichs DE. MicrobiologyOpen. 2014 Feb 7. doi: 10.1002/mbo3.162. [Epub ahead of print]

Rytelewski M, Meilleur CE, Atef Yekta M, Szabo PA, Garg N, Schell TD, Jevnikar AM, Sharif S, Singh B, Haeryfar SM: Suppression of immunodominant antitumor and antiviral CD8+ T cell responses by indoleamine 2,3-dioxygenase. PLoS ONE 2014 (accepted)

Antihomocitrullinated Fibrinogen Antibodies are Specific to Rheumatoid Arthritis and Frequently Bind Citrullinated Proteins/peptides. Scinocca M, Bell DA, Racapé M, Joseph R, Shaw G, McCormick JK, Gladman DD, Pope J, Barra L, Cairns E. J Rheumatol. 2014 Jan 15. [Epub ahead of print]

Functional analysis of the C-terminal region of human adenovirus E1A reveals a misidentified nuclear localization signal Michael J. Cohen, Cason R. King, Jimmy D. Dikeakos, Joe S. Mymryk Virology, 468–470, November 2014, Pages 238–243

Lentivector integration sites in ependymal cells from a model of metachromatic leukodystrophy: non-B DNA as a new factor influencing integration. McAllister RG, Liu J, Woods MW, Tom SK, Rupar CA, Barr SD. Molecular Therapy Nucleic Acids. 2014 Aug 26;3:e187

The Multifunctional Sorting Protein PACS-2 Regulates SIRT1-Mediated Deacetylation of p53 to Modulate p21-Dependent Cell-Cycle Arrest. Katelyn M. Atkins, Laura L. Thomas, Jonathan Barroso-González, Laurel Thomas, Sylvain Auclair, Jun Yin, Hyeog Kang, Jay H. Chung, Jimmy D. Dikeakos, Gary Thomas.

Rytelewski M, Buensuceso A, Leong HS, Deroo BJ, Chambers AF, Koropatnick J. Evaluating the effectiveness of cancer drug sensitization in vitro and in vivo. JoVE (In press August 2014)

Identification of a positively-charged platform in Staphylococcus aureus HtsA that is essential for ferric staphyloferrin A transport. Cooper JD, Hannauer M, Marolda CL, Briere LA, Heinrichs DE., Biochemistry. 2014 Jul 22. [Epub ahead of print]

Lau A; Khan K; Pavlosky A; Yin Z; Huang X; Haig A; Liu W; Singh B; Zhang ZX; Jevnikar AM. Serine Protease Inhibitor-6 Inhibits Granzyme B-Mediated Injury of Renal Tubular Cells and Promotes Renal Allograft Survival. Transplantation; 2014 Jun (in press); PubMed ID: 24918613

Bellemore SM; Nikoopour E; Au BC; Krougly O; Lee-Chan E; Haeryfar SM; Singh B. Anti-atherogenic peptide Ep1.B derived from Apolipoprotein E induces tolerogenic plasmacytoid dendritic cells. Clin Exp Immunol; 2014 May (in press); PubMed ID: 24784480

Nikoopour E, Singh B. Reciprocity in microbiome and immune system interactions and its implications in disease and health. Inflamm Allergy Drug Targets; 2014 Apr 13; 13(2):94-104. PubMed ID: 24678760

Anantha, R.V., D. Mazzuca, S. X. Xu. B. Shrum, T. Mele, D. Fraser, C. Martin, S.M. Haeryfar, J. K. McCormick. Th2-polarized invariant natural killer T cells reduce disease severity in intra-abdominal sepsis. Clinical and Experimental Immunology. In press.

S Meshkibaf, MW Gower, GA Dekaban and SO Kim: G-CSF preferentially supports the generation of gut-homing Gr-1high macrophages in M-CSF-treated bone marrow cells. Journal of Leukocyte Biology (accepted)

Xu, S. X., K. J. Gilmore, P. A. Szabo, J. J. Zeppa, M. L. Baroja, S. M. M. Haeryfar, and J. K. McCormick. Superantigens subvert the neutrophil response to promote abscess formation and enhance Staphylococcus aureus survival in vivo. Infection and Immunity. In press.

Ancient and Recent Adaptive Evolution in the Antiviral TRIM22 Gene: Identification of a Single Nucleotide Polymorphism that Impacts TRIM22 Function. 2014. Jenna N. Kelly, Matthew W. Woods, Sintia Xhiku and Stephen D. Barr. Human Mutation. Accepted manuscript online: 26 MAY 2014 10:39PM EST | DOI: 10.1002/humu.22595

Reid, G. 2014. Modulating the vaginal microbiome: the need for a bridge between science and practice. Semin Reprod Med. 32(1):28-34

Yang, S, W. Li, J. R.G. Challis, G. Reid, S. O. Kim, and A. D. Bocking. 2014. Probiotic Lactobacillus rhamnosus GR-1 supernatant prevents lipopolysaccharide-induced preterm birth and reduces inflammation in pregnant CD-1 mice. Am. J. Obstetr. Gynecol. 211(1):44.e1-44.e12.

Goneau, L. W., N. S. Yeoh, K. W. MacDonald, P. Cadieux, J. P. Burton, and G. Reid. 2014. Selective antibiotic target inactivation results in persister cell formation and is associated with recurrent urinary tract infection.Antimicrob. Agents Chemother. 58(4):2089-97.

Li, W., S. Yang, S. O. Kim, G. Reid, J. R. Challis, and A. D. Bocking. 2014. Lipopolysaccharide-induced profiles of cytokine, chemokine, and growth factors produced by human decidual cells are altered by Lactobacillus rhamnosus GR-1 supernatant. Reprod Sci. 21(7):939-947.

Reid, G., N. Nduti, W. Sybesma, R. Kort, T. R. Kollmann, R. Adam, H. Boga, E. M. Brown, A. Einerhand, H. El-Nezami, G. B. Gloor, I. I. Kavere, J. Lindahl, A. Manges, W. Mamo, R. Martin, A. McMillan, J. Obiero, P. A. Ochieng', A. Onyango, S. Rulisa, E. Salminen, S. Salminen, A. Sije, J. R. Swann, W. Van Treuren, D. Waweru, and S. Kemp. 2014. Harnessing microbiome and probiotic research in sub-Saharan Africa: recommendations from an African workshop. Microbiome 2:12. DOI: 10.1186/2049-2618-2-12

Sheridan, P. O., L. Bindels, D. M. Saulnier, G. Reid, E. Nova, K. Holmgren, P. W. O’Toole, N. Delzenne, and K. P. Scott. 2014. Can prebiotics and probiotics improve therapeutic outcomes of undernourished individuals? Gut Microbes 5(1):74-82.

Chaban, B., M. G. Links, T. P. Jayaprakash, E. Wagner, D. Bourque, Z. Lohn, A. Y.K. Albert, J. van Schalkwyk, G. Reid, S. Hemmingsen, J. E. Hill, and D. Money. 2014. Characterization of the vaginal microbiome of healthy Canadian women through the menstrual cycle. Microbiome in press.

Hill, C., F. Guarner, G. Reid, G. Gibson, D. Merenstein, B. Pot, L. Morelli, R. Canani, H. Flint, S. Salminen, P. Calder, and M. E. Sanders. 2014. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotics. Nat. Reviews Gastroenterol. Hepatol. June 10 online

Urbaniak, C., A. McMillan, M. Angelini, G. B. Gloor, M. Sumarah, J. P. Burton and G. Reid, 2014. Case study: Effect of chemotherapy on the microbiome and metabolome of human milk. Microbiome 2: 24.

Gan X., T., G. Ettinger, C. X. Huang, J. P. Burton, J. V. Haist, V. Rajapurohitam, J. E. Sidaway, G. Martin, G. B. Gloor, J. R. Swann, G. Reid, and Karmazyn, M. 2013. Probiotic administration attenuates myocardial hypertrophy and heart failure following myocardial infarction in the rat. Circul. Heart Failure 7(3):491-9.

Bisanz, J. E., S. Seney, A. McMillan, R. Vongsa, D. Koenig, L-F.Wong, B. Dvoracek, G.B. Gloor, M. Sumarah, B. Ford, D. Herman, J. P. Burton, and G. Reid. 2014. A systems biology approach investigating the effect of Lactobacillus rhamnosus GR-1 and L. reuteri RC-14 on the vaginal microbiome and host responses in a double blind, placebo-controlled clinical trial of post-menopausal women with intermediate Nugent scores. PLoS ONE in press.

Bisanz, J. E., J. M. Macklaim, G. B. Gloor, and G. Reid. 2014. Bacterial metatranscriptome analysis of a probiotic yogurt using an RNA-Seq approach. Int Dairy J. in press. Jenna Kelly and Stephen Barr. In Silico Analysis of Functional Single Nucleotide Polymorphisms in the Human TRIM22 Gene. PLoS One 2014 Jul 1; 9(7):e101436