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Publications

Selected Publications

• Molecular basis for the interaction between stress-inducible phosphoprotein 1 (STIP1) and S100A1. Maciejewski, A., Prado, V.F., Prado, M.A.M., Choy, W.Y. Biochem J. May 16;474(11):1853-1866. 2017

• Parkin-phosphoubiquitin Complex Reveals a Cryptic Ubiquitin Binding Site Required for RBR Ligase Activity. Kumar, A., Chaugule, V., Condos, T.E.C., Barber, K.R., Johnson, C., Toth, R., Sundaramoorthy, R., Knebel, A., Shaw, G.S. & Walden, H. Nature Str. Mol. Biol. 24, 475-483. 2017. Online version

• Structure of Phosphorylated UBL Domain and Insights into PINK1-orchestrated Parkin Activation. Aguirre, J.D., Dunkerley, K., Mercier, P. & Shaw, G.S.  Proc. Nat. Acad. Sci. 114, 298-303. 2017. Online version

• Structural perturbations induced by Asn131 and Asn171 glycosylation converge within the EFSAM core and enhance stromal interaction molecule-1 mediated store operated calcium entry. Choi, Y.J., Zhao, Y., Bhattacharya, M., Stathopulos, P.B. Biochim Biophys Acta. 2017 Jun;1864(6):1054-1063.

• Domains of STIP1 responsible for regulating PrP^C-dependent amyloid-β oligomer toxicity. Maciejewski, A., Ostapchenko, V.G., Beraldo, F.H., Prado, V.F., Prado, M.A.M., Choy, W.Y. Biochem J. Jul 15;473(14):2119-30. 2016

• Suramin Inhibits Cullin-RING E3 Ligases. Wu, K., Chong, R.A., Yu, Q., Bai, J., Spratt, D.E., Ching, K., Lee, C., Miao, H., Tappin, I., Hurwitz, J., Zheng, N., Shaw, G.S., Sun, Y., Felsenfeld, D.P., Sanchez, R., Zheng, J-N. & Pan, Z-Q Proc. Natl. Acad. Sci. 113, E2011-2018. 2016 Online version

• Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis. EMBO J. Kumar, A., Aguirre, J.D., Condos, T.E.C., Martinex-Torres, R.J., Chaugule, V.K., Toth, R., Sundaramoorthy, R., Mercier, P., Knebel, A., Spratt, D.E., Barber, K.R., Shaw, G.S. & Walden, H. 2015 . Online version

• Generation of Phospho-ubiquitin Variants by Orthogonal Translation Reveals Codon Skipping. George, S., Aguirre, J.D., Spratt, D.E., Bi, Y., Jeffrey, M., Shaw, G.S. & O'Donoghue, P.  FEBS Letts. 590, 1530-1542. 2016 Online version

• Structural perturbations induced by Asn131 and Asn171 glycosylation converge within the EFSAM core and enhance stromal interaction molecule-1 mediated store operated calcium entry.  Choi YJ, Zhao Y, Bhattacharya M, Stathopulos PB. Biochim Biophys Acta. 2016 Nov 17

• Conformational characterization of the intrinsically disordered protein Chibby: Interplay between structural elements in target recognition. Killoran RC, Sowole MA, Halim MA, Konermann L, Choy WY. Protein Sci. 2016 Aug;25(8):1420-9

• Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis. Kumar A, Aguirre JD, Condos TE, Martinez-Torres RJ, Chaugule VK, Toth R, Sundaramoorthy R, Mercier P, Knebel A, Spratt DE, Barber KR, Shaw GS, Walden H. EMBO J. 2015 Oct 14;34(20):2506-21

• Structural Analysis of the 14-3-3ζ/Chibby Interaction Involved in Wnt/β-Catenin Signaling. Killoran RC, Fan J, Yang D, Shilton BH, Choy WY. PLoS One. 2015 Apr 24;10(4)

• Molecular effects of cancer-associated somatic mutations on the structural and target recognition properties of Keap1. Khan H, Killoran RC, Brickenden A, Fan J, Yang D, Choy WY. Biochem J. 2015 Apr 1;467(1):141-51

• A molecular explanation for the recessive nature of parkin-linked Parkinson's disease. Spratt DE, Martinez-Torres RJ, Noh YJ, Mercier P, Manczyk N, Barber KR, Aguirre JD, Burchell L, Purkiss A, Walden H, Shaw GS. Nat Commun. 2013;4:1983