Schulich school of Medicine and Dentistry logo Biomolecular NMR Facility Schulich School of Medicine & Dentistry
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Welcome to the Biomolecular NMR Facility

The Biomolecular NMR Facility is an open access research facility located in the Department of Biochemistry in the Schulich School of Medicine

The facility houses two high field NMR instruments (Varian INOVA 600 MHz), and a variety of accessories including detection of a wide variety of nuclei, broad sample temperature capabilities and cryogenically cooled high sensitivity hydrogen and carbon probes for enhanced sensitivity. 

The facility is available to researchers who wish to conduct and analyze their own NMR experiments, or submit samples on a fee-for-service basis. We are also available to discuss your research project with you and help develop experiments that may address your biological questions.

Our facility serves the Department of Biochemistry and many other departments in the Schulich School of Medicine and Dentistry and Western University, as well as external research institutions and commercial clients.  

How Can NMR Help Your Research

 Some of the capabilities of the facility include:

 Characterization of small biological molecules        

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      Identification of new compounds
      Enzyme kinetics
      Characterization of contaminants
      Metabolomics in biofluids

 

 

Three dimensional structure determination of soluble proteins in solution

Capabilities_3Dstructure.png       Identification of new protein folds
       Observation of flexible or stable conformations
       Hydrodynamic radii determination 

 

 

Drug and receptor interaction

       Binding locations on a per residue level
       Binding affinities and kinetics

 

 

 

Protein Dynamics

        Conformational changes on picosecond-
        to-second timescales.

 

 

 

Protein Interactions   

          Mapping of protein-protein and protein-ligand
          binding interfaces.