Schulich school of Medicine and Dentistry logo Clinical Neurological Sciences Schulich School of Medicine & Dentistry

Glial Biology/ Pain Neuro-oncology

Description

The Glial Biology/Neuro-oncology program provides a multidisciplinary team of specialists in neurosurgery and neurology with close collaborations with hematology/oncology, radiation oncology, neuropathology and radiology. The team employs aggressive treatment protocols involving state-of-the-art techniques and advanced diagnostics and treatments available to patients with benign and malignant tumors of the brain and spine. By combining the best in current clinical treatments, along with cutting edge research, the department is able to offer state-of-the-art treatment for patients.

The CNS Pain Program includes multidisciplinary pain clinics in non-cancer neuropathic pain and cancer-related pain. The non-cancer Neuropathic Pain Clinic is the only pain clinic devoted solely to neuropathic pain in Canada and is held at the St Joseph’s Pain Clinic on Fridays under the direction of Dr Dwight Moulin. Management of neuropathic pain is guided by the Canadian Consensus Guidelines on Neuropathic Pain(2014) which originated at our centre. The cancer pain clinic is known as the Pain and Symptom Clinic and is held every Tuesday and Thursday afternoon at the London Regional Cancer Program(LRCP). This clinic deals with cancer pain related to the disease process and to treatment and involves a neuro-oncologist(Dr Dwight Moulin) with input from medical and radiation oncologists, nurses, social workers and other allied health workers at LRCP.

Training Opportunities

Residents

During scheduled academic half-days, neurology residents will study pain topics including:

  • Core Topics
    • Neuropathic pain and its treatment Cancer pain syndromes
  • Special Topics
    • Basic neuroscience Pain pathways
    • Migraine pathophysiology
    • Pathophysiology of neuropathic pain

During scheduled academic half-days, neurology residents will study neuro-oncology topics including:

  • Core Topics
    • Primary brain and spinal cord tumours
    • Metastatic involvement of the nervous system
    • Paraneoplastic syndromes Neuroradiology of brain tumours
  • Special Topics
    • Neuropathology: primary brain tumours
    • Basic neuroscience: molecular biology of brain tumour development

Neurosurgery residents will study neurosurgical techniques including:

  • Intracranial intra-axial tumor dissection and removal
  • Craniectomy for posterior fossa tumors
  • supra/infratentorial craniotomy for complex  tumors

Residents can also complete a neuro-oncology rotation.

Learn more about CNS Residency programs.

Neuro-oncology Fellowship

Main Contact: David Macdonald - MD, FRCPC

phone: 519-685-8640
fax: 519-685-8624
London Regional Cancer Centre
Medical Oncology, Room 3056
790 Commissioners Road East
London Ontario Canada
N6A 4L6

Fellowship application information.

Pain Fellowship

Main Contact: Dwight E. Moulin - MD, FRCPC

phone: 519-685-8661
fax: 519-685-8636
London Regional Cancer Program
790 Commissioners Road East
London, Ontario, N6A 4L6

Fellowship applicaiton information.

Post-Doctoral, Graduate, and Undergraduate

CNS offers training opportunities for residents in glial biology and neuro-oncology research. Opportunities for MSc, PhD, and Postdoctoral candidates are also available upon request. Dr. Hebb has acted as a primary supervisor to postdoctoral fellows conducting research on intratumoral modulation therapy for glioblastoma as well as many other projects. He has also acted as a co-supervisor to masters students conducting research on the application of electrotherapeutics in glioblastoma. Dr. Megyesi has acted as a primary supervisor on numerous resident research projects and clinical fellowships. Dr. Watling has acted as a supervisor and co-supervisor to MSc and PhD candidates.

Research Opportunities

If you are interested in conducting research in glial biology, pain, or neuro-oncology or are interested in assisting in ongoing research by our faculty, visit their bio pages for information on their specific research interests and how to get in touch.

Recent Glial Biology/ Pain Neuro-oncology Publications

Wen PY, Chang SM, Van den Bent MJ, Vogelbaum MA, Macdonald DR, Lee EQ. Response Assessment in Neuro-Oncology Clinical Trials. J Clin Oncol. 2017 Jul 20;35(21):2439-2449. doi: 10.1200/JCO.2017.72.7511. Epub 2017 Jun 22. PMID: 28640707

Avila EK, Chamberlain M, Schiff D, Reijneveld JC, Armstrong TS, Ruda R, Wen PY, Weller M, Koekkoek JA, Mittal S, Arakawa Y, Choucair A, Gonzalez-Martinez J, MacDonald DR, Nishikawa R, Shah A, Vecht CJ, Warren P, van den Bent MJ, DeAngelis LM. Seizure control as a new metric in assessing efficacy of tumor treatment in low-grade glioma trials. Neuro Oncol. 2017 Jan;19(1):12-21. doi: 10.1093/neuonc/now190. Epub 2016 Sep 20. Review. PMID: 27651472

VanDenKerkhof EG, Stitt L, Clark AJ, Gordon A, Lynch M, Morley-Forster PK, Nathan HJ, Smyth C, Toth C, Ware MA, Moulin DE. Sensitivity of the DN4 in Screening for Neuropathic Pain Syndromes. Clin J Pain. 2017 May 5. doi: 10.1097/AJP.0000000000000512. [Epub ahead of print] PMID: 28481836

Ng WP, Liew BS, Idris Z, Rosman AK. Fluorescence-Guided versus Conventional Surgical Resection of High Grade Glioma: A Single-Centre, 7-Year, Comparative Effectiveness Study. Malays J Med Sci. 2017 Mar;24(2):78-86. doi: 10.21315/m

Bostick GP, Kamper SJ, Haanstra TM, Dick BD, Stitt LW, Morley-Forster P, Clark AJ, Lynch ME, Gordon A, Nathan H, Smyth C, Ware MA, Toth C, Moulin DE. Pain expectations in neuropathic pain: Is it best to be optimistic? Eur J Pain. 2017 Apr;21(4):605-613. doi: 10.1002/ejp.962. Epub 2016 Oct 14. PMID: 27739623

Shadd JD, Ryan BL, Maddocks HL, McKay SD, Moulin DE. Neuropathic pain in a primary care electronic health record database. Eur J Pain. 2015 May;19(5):715-21. doi: 10.1002/ejp.594. Epub 2014 Dec 12. PMID: 25504680

Faculty

Neurologists

Neurosurgeons