Vladimir Hachinski, CM, MD, DSc, FRCPC, Doctor honoris causaX4

hachinski

Professor of Neurology and Epidemiology, Western University; Distinguished University Professor
Office: London Health Sciences Centre, University Hospital B7-003
Phone: 519-663-3624
Secretary: Rebecca Clarke

 

 

Bio Sketch

Dr. Vladimir Hachinski received his MD from the University of Toronto. After completing his residency training at the same university, he undertook a Cerebrovascular Laboratory fellowship at the National Hospital for Nervous Diseases at Queen Square in London, England and a research fellowship at Bispebjerg Hospital in Copenhagen, Denmark.

Dr. Hachinski is Professor of Neurology and Distinguished University Professor at Western University. He founded, with John W. Norris the first successful acute stroke unit which has become the standard of care and with David Cechetto discovered the key role of the insula of the brain in mediating sudden death. He introduced the concepts and terms multi-infarct dementia, leukoaraiosis and vascular cognitive impairment and devised the Hachinski ischemic score, which remains the standard for identifying a vascular (treatable) component of cognitive impairment.

Dr. Hachinski was Editor-in-Chief of the journal Stroke, the leading publication in the field for an unprecedented 10 year term from 2000-2010. He introduced 9 international editions and a unique author mentorship program. He has contributed over 800 scientific papers, book chapters, editorials and other scholarly publications, with over 27,000 citations and an H-Index of 79. He is the author, co-author or editor or co-editor of 17 books including Stroke: A Comprehensive Guide to Brain Attack, co-authored with his daughter Larissa Hachinski, which was written to increase public awareness of brain attack, a term coined by Dr. Hachinski to help drive home the urgency of strokes.

He has received 4 honorary doctorates, the Mihara International Award, World Stroke Organization Leadership in Stroke Medicine Award, the Premier's Discovery Award in the Life Sciences and Medicine for "ground breaking research on relationship between stroke and Alzheimer disease". Dr. Hachinski was the founding Chair of the International Society for Vascular Behavioural and Cognitive Disorders and President of the World Federation of Neurology, 2010-2013. He is Vice President of the World Stroke Organization. He was awarded the 2011 International BIAL Merit Award in Medical Sciences for a monograph on "The Long Fuse: Silent Strokes and Insidious Alzheimer Disease" and in 2012 a Doctor honoris causa from the Russian Academy of Medical Sciences. In 2008 he received the Order of Canada and in 2013 the Order of Ontario and the Queen Elizabeth II Diamond Jubilee Medal. He was the 2013 Paddison Lecturer and was awarded the Chancellor's Award Lecture in Neuroscience and Neurology for his "contributions to neurological sciences and for outstanding academic leadership" at the University of Louisiana. Dr. Hachinski was the Allan & Maria Myers International Visiting Fellow for 2014 at the Florey Institute in Melbourne, Australia and was the 2014 Brain Scholar, Cambridge, Oxford and London UK Universities. 


 

Research

Dr. Hachinski coordinates a group involved in experimental, clinical and population studies in the prevention of stroke and delay of Alzheimer disease.
Experimental

With David F. Cechetto and Shawn Whitehead of Western's Department of Anatomy and Cell Biology, he observed in Alzheimer animal models that the presence of the protein amyloid is associated with inflammation and brain damage when a stroke is induced and that this can be prevented with anti-inflammatory drugs. Alexander Thiel (Montreal) has begun studies in patients to confirm their experimental findings.

Clinical Trials

The PARTNERS Study

He is co-principal investigator of a Canada wide CIHR funded multi-center study led by Richard Chan, using trained volunteers to work with high-risk patients for better control of blood pressure and other vascular risk factors to prevent stroke and cognitive decline.

Population

Executive dysfunction as an early warning system of stroke and preventable cognitive decline.
Collaborators: Miia Kivipelto, Karolinska Institute, Stockholm, Sweden; David Bennett, Rush University, Chicago.

Studies of electronic versions of the Montreal Cognitive Assessment tool (MoCA) and the Hachinski ischemic score.
Collaborators: Ziad Nasreddine, inventor of MoCA (Montreal), Anne Snowdon, Chair, International Centre for Health Innovation, Richard Ivey Business School, William Shankle, Cognitive Science Department, University of California, Irvine.

Neuroscience

Handedness and brain patterns of cardiovascular control

Collaborators: David Cechetto, Department of Anatomy and Cell Biology, Western University, Kevin Shoemaker, Faculty of Health Sciences, Western University, Mark Daley, Faculty of Science, Western University
The brain and rhythm preferences: Constants and variations, implications and applications
Collaborators: Jessica Grahn, Faculty of Social Science, Department of Psychology, Western University, Jason Stanford, Don Wright Faculty of Music, Western University, Betty Anne Younker, Dean of the Don Wright Faculty of Music, Western University based on a Dream Waltz by Hachinski and Jason Stanford, premiered at the Musikverein in Vienna, Austria, September 24, 2013.

Research Opportunities

Research projects for residents in neurology and fellowships for those who have completed their training are available. Contact: vladimir.hachinski@lhsc.on.ca 


Medical Interests

Dementia, Alzheimer's Disease, Stroke Prevention


Honours and Awards

  • 2018, Killam Prize, Canadian Council for the Arts
  • 2017, Canadian Medical Hall of Fame
  • 2016, McLaughlin Medal, Royal Society of Canada
  • 2015, Lawson Career Scientist Award, Lawson Research Institute
  • 2013, Officer of the Order of Ontario
  • 2013, Queen Elizabeth II Diamond Jubilee Medal
  • 2013, Chancellor's Award Lecture in Neuroscience and Neurology
  • 2011, International BIAL Merit Award in Medical Sciences, BILAL
  • 2010, Biomedical Science Ambassador Award, Canadian national charity Partners In Research
  • 2008, Honorary Member, Mexican Academy of Neurology
  • 2008, Mihara International Award
  • 2008, World Stroke Organization Leadership in Stroke Medicine Award
  • 2008, Premier's Discovery Award in the Life Sciences and Medicine
  • 2008, Officer of the Order of Canada
  • 2008, Mihara International Award
  • 2006, Distinguished Professor, Western University

Publications

PubMed Publications Listing

Publications

Azarpazhooh MR, Avan A, Cipriano LE, Munoz DG, Sposato LA, Hachinski V. Concomitant vascular and neurodegenerative pathologies double the risk of dementia. Alzheimers Dement. 2017 Sep 30. pii: S1552-5260(17)33686-5. doi: 10.1016/j.jalz.2017.07.755. [Epub ahead of print] PubMed PMID: 28974416.

Levit A, Regis AM, Garabon JR, Oh SH, Desai SJ, Rajakumar N, Hachinski V, Agca Y, Agca C, Whitehead SN, Allman BL. Behavioural inflexibility in a comorbid rat model of striatal ischemic injury and mutant hAPP overexpression. Behav Brain Res. 2017 Aug 30;333:267-275. doi: 10.1016/j.bbr.2017.07.006. Epub 2017 Jul 8. PubMed PMID: 28693862.

Nucera A, Azarpazhooh MR, Alsubaie R, Riccio P, Hachinski V. Time is brain: Balancing risk in the treatment of presumed cardioembolic stroke. J Neurol Sci. 2017 Jul 21. pii: S0022-510X(17)30458-6. doi: 10.1016/j.jns.2017.07.022. [Epub ahead of print] PubMed PMID: 28778583.

Prior PL, Hachinski V, Chan R, Unsworth K, Mytka S, Harnadek M, OʼCallaghan C, Suskin N. Comprehensive Cardiac Rehabilitation for Secondary Prevention After Transient Ischemic Attack or Mild Stroke: PSYCHOLOGICAL PROFILE AND OUTCOMES. J Cardiopulm Rehabil Prev. 2017 Jul 19. doi: 10.1097/HCR.0000000000000274. [Epub ahead of print] PubMed PMID: 28727668.

Levit A, Regis AM, Garabon JR, Oh SH, Desai S, Rajakumar N, Hachinski V, Agca Y, Agca C, Whitehead SN, Allman BL. Behavioural inflexibility in a comorbid rat model of striatal ischemic injury and mutant hAPP overexpression. Behav Brain Res. 2017 Jul 7. pii: S0166-4328(17)30488-6. doi: 10.1016/j.bbr.2017.07.006. [Epub ahead of print] PubMed PMID: 28693862.

Montero-Odasso MM, Sarquis-Adamson Y, Speechley M, Borrie MJ, Hachinski VC, Wells J, Riccio PM, Schapira M, Sejdic E, Camicioli RM, Bartha R, McIlroy WE, Muir-Hunter S. Association of Dual-Task Gait With Incident Dementia in Mild Cognitive Impairment: Results From the Gait and Brain Study. JAMA Neurol. 2017 Jul 1;74(7):857-865. doi: 10.1001/jamaneurol.2017.0643. PMID: 28505243

Hachinski V, Alsubaie R, Azarpazhooh MR. Upgoing thumb sign: A sensitive indicator of brain involvement? Neurology. 2017 Jun 28. pii: 10.1212/WNL.0000000000004157. doi: 10.1212/WNL.0000000000004157. [Epub ahead of print] PubMed PMID: 28659430.

Azarpazhooh MR, Hachinski V. Optimisation of stroke research. Lancet Neurol. 2017 May;16(5):340-341. doi: 10.1016/S1474-4422(17)30081-9. No abstract available. PMID: 28414643

Hachinski V. Stoop to conquer: preventing stroke and dementia together. Lancet. 2017 Apr 15;389(10078):1518. doi:  10.1016/S0140-6736(17)30954-6. No abstract available. PMID: 28422027

Gregory MA, Boa Sorte Silva NC, Gill DP, McGowan CL, Liu-Ambrose T, Shoemaker JK, Hachinski V, Holmes J, Petrella RJ. Combined Dual-Task Gait Training and Aerobic Exercise to Improve Cognition, Mobility, and Vascular Health in Community-Dwelling Older Adults at Risk for Future Cognitive Decline1. J Alzheimers Dis. 2017;57(3):747-763. doi: 10.3233/JAD-161240. PMID: 28304305

Patel SK, Restrepo C, Werden E, Churilov L, Ekinci EI, Srivastava PM, Ramchand J, Wai B, Chambers B, O'Callaghan CJ, Darby D, Hachinski V, Cumming T, Donnan G, Burrell LM, Brodtmann A. Does left ventricular hypertrophy affect cognition and brain structural integrity in type 2 diabetes? Study design and rationale of the Diabetes and Dementia (D2) study. BMC Endocr Disord. 2017 Apr 7;17(1):24. doi: 10.1186/s12902-017-0173-7. PMID: 2838889

Cerasuolo JO, Cipriano LE, Sposato LA, Kapral MK, Fang J, Gill SS, Hackam DG, Hachinski V. Population-based stroke and dementia incidence trends: Age and sex variations. Alzheimers Dement. 2017 Mar 28. pii: S1552-5260(17)30095-X. doi: 10.1016/j.jalz.2017.02.010. [Epub ahead of print] PMID: 28363085

Lee SA, Sposato LA, Hachinski V, Cipriano LE. Cost-effectiveness of cerebrospinal biomarkers for the diagnosis of Alzheimer's disease. Alzheimers Res Ther. 2017 Mar 16;9(1):18. doi: 10.1186/s13195-017-0243-0. PMID: 28302164

Sposato LA, Wardlaw JM, Hachinski V. Response by Sposato et al to Letter Regarding Article, "Effect of Right Insular Involvement on Death and Functional Outcome After Acute Ischemic Stroke in the IST-3 Trial (Third International Stroke Trial)". Stroke. 2017 Mar;48(3):e92. doi: 10.1161/STROKEAHA.116.016387. Epub 2017 Feb 7. No abstract available. PMID: 28174325

Hachinski V. Henry J.M. Barnett, MD (1922-2016). Neurology. 2017 Feb 28;88(9):824-825. doi: 10.1212/WNL.0000000000003668. No abstract available. PMID:28242847

Oveisgharan S, Hachinski V. Atherosclerosis and vascular cognitive impairment neuropathological guideline. Brain. 2017 Feb;140(Pt 2):e12. doi: 10.1093/brain/aww304. Epub 2016 Dec 21. No abstract available. PMID: 28007992

Sposato LA, Hachinski V. Right insular cortex involvement is consistently associated with death after ischaemic stroke. Eur J Neurol. 2017 Jan;24(1):1-2. doi: 10.1111/ene.13174. Epub 2016 Oct 31. No abstract available. PMID: 27797138

Spence JD, Hachinski V. Henry J.M. Barnett: 1922-2016. Stroke. 2017 Jan;48(1):2-4. doi: 10.1161/STROKEAHA.116.015868. Epub 2016 Dec 8. No abstract available. PMID: 27932605

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