Schulich school of Medicine and Dentistry logo Anesthesia and Perioperative Medicine Schulich School of Medicine & Dentistry

Centre for Medical Evidence, Decision Integrity & Clinical Impact (MEDICI)

DIEESC

The Centre for Medical Evidence, Decision Integrity & Clinical Impact (MEDICI) was established in 2011 with the support of the Schulich School of Medicine and Dentistry, London Health Sciences Centre, St. Joseph’s Health Care London and Lawson Research. 

MEDICI incorporates:

MEDICI has three key mandates:

  1. Practice & Policy: To provide timely, contextualized evidence syntheses to enable real-world evidence-informed decision-making related to drugs, devices, procedures and programs with a special focus on:
    1. hospital based decision-making at the local level, and with application also to regional, national, and international healthcare decision-making;
    2. global surgery, anesthesia & perioperative care;
  2. Education: To provide educational and capacity-building opportunities in evidence-informed decision-making, health technology assessment, health economics, health policy, and knowledge translation locally, nationally, and internationally in the developed and developing world;
  3. Research: To conduct cutting-edge research to advance the front of health technology assessment, economic analysis, health policy analysis, decision-making science and knowledge translation in the developing and developed world.

Highlights

In 2015, MEDICI was invited to contribute to a number of global surgery initiatives at the WHO in Geneva.

Janet Martin, Davy Cheng, and Jennifer Vergel de Dios published, “Survey of the capacity for essential surgery and anaesthesia services in Papua New Guinea”, in collaboration with WHO GIEESC.

Dr. Martin and Dr. Cheng led the development of WHO Guidelines for Screening, Diagnosis, Triage, and Management of Patients Presenting for Surgery in the Context of Ebola Virus Disease (EVD) and Other Viral Haemorrhagic Fevers (VHF). 

MEDICI is continuing to work with the WHO to:

  • Develop evidence-informed context-sensitive guidelines
  • Advocate for development of capacity for essential surgery, anesthesia, emergency and critical care in resource-poor settings as a component of Universal Health Care
  • Provide workshops and capacity-building in evidence-informed decision-making in essential surgery and anesthesia contextualized to resource-poor settings

GIEESC

Left to Right: Dr. Amelia Contreras Palomino, Gastroenterology, Stuttgart, Germany; Dr. Davy Cheng, Distinguished University Professor and Chair/Chief of the Department of Anesthesia and Perioperative Medicine and Medical Director of MEDICI, Western University; Dr. Meena Cherian, EESC Program Director, WHO; Dr. Edward Kelly, Director of Service, Delivery & Safety, WHO and Health Systems & Innovation, WHO; and Janet Martin, Assistant Professor and Director of MEDICI, Western University

December 2015

  • Drs. Cheng & Martin were invited to the WHO's 10th anniversary of GIEESC, at WHO headquarters, Switzerland.  Dr. Cheng represented the Department of Anesthesia and Perioperative Medicine, as well as the Scientific Affairs Committee of the World Federation of Societies of Anesthesiologists (WFSA). Dr. Martin chaired a working group on Data Metrics and Quality Indicators in Emergency and Essential Surgery and Anesthesia Care.
  • Desiree Sutton, MSc(epi) candidate, successfully defends her thesis on “Evidence Reversals”, under the supervision of Dr. Martin.
  • Dr. Martin is Invited Professor at City University, London, UK to present “What proportion of evidence is valid and relevant?”
  • Dr. Martin contributes to “Hellish Decisions” course at Oxford University, Oxford, UK

November 2015

  • Dr. Cheng and Dr. Martin lead the ISMICS conference on Transcatheter Aortic Valve Intervention (TAVI), based on MEDICI’s series of meta-analyses on TAVI vs surgical aortic valve replacement in high-risk patients, and TAVI versus medical management in patients ineligible for surgery.

October 2015

  • Dr. Martin presents MEDICI research on “Evidence: What Proportion is Valid and Relevant?” at the International Evidence-Based Health Care Conference in Sicily.
  • Dr. Martin completes her term on the Scientific Committee for the Evidence Based Health Care meeting in Sicily, Italy. 

September 2015

  • Dr. Martin delivers the case-based interactive Clinical Epidemiology course for the MSc(epi) program at the Epidemiology & Biostatistics Department, Western. Dr. Philip Jones is a frequent contributor to the course, with guest lectures on Diagnosis & Screening, Prognosis & Harm, and Clinical Trials & Evidence Integrity. The final exam was a lively court-case debate on a series of evidence-informed topics.

September 2015

  • Dr. Ava John-Baptiste, Health Economist for MEDICI, elected as one of three Trustees for the Society of Medical Decision Making (SMDM)
  • Riaz Qureshi begins his research at MEDICI as a Masters student in epidemiology, under the supervision of Dr. Martin
  • Dr. Jennifer Vergel de Dios joins MEDICI as Global Health Fellow
  • Dr. Junsong Gong and Dr. Jingyi Li join as Postdoctoral Fellows
  • Dr. Martin speaks at the Decision-Making Institute, hosted by THETA, University of Toronto

July 2015

June 2015

  • The MEDICI team presents an interactive workshop on Anesthesia Evidence at the CAS Annual Meeting, Ottawa

Summer 2015

  • Dr. Angel Zhu, Brenda Tibingana, Jessica Moodie, Amy Newitt and Peter Zhang (summer student) apply text mining to automate systematic review searching for Maternal-Neonatal Perioperative Mortality
  • Dr. Atoosa Enzevaei, Critical Care Fellow, completes research rotation at MEDICI, contributing to Critical Care Evidence Validity & Relevance
  • Dr. Matt Chong completes a research rotation at MEDICI, contributing to Anesthesia Evidence Validity & Relevance, and also multiple meta-analyses

May 2015

  • Dr. Martin is Invited Professor at Barcelona University’s School of Economics, to deliver a course on Health Technology Assessment & Decision-Making
  • MEDICI presentation on Safe Surgery Checklist Relevance for Developed and Developing Countries at Euroanesthesia in Berlin is profiled in media outlets, including MedicalResearch.com, Medscape News, and AAAS

April 2015

  • Dr. Martin participates on two panels on ‘HTA & Innovations in Decision-Making using Know4Go’ at the Canadian Agency for Drugs and Technologies in Health Symposium
  • Dr. Martin completes her term as Chair, HTA Exchange, and welcomes Dr. Murray Krahn, THETA as in-coming Chair

March 2015

  • Dr. Cheng and Dr. Martin present an interactive workshop on “Anesthesia Evidence: Validity and Relevance” at the IARS Meeting in collaboration with Dr. Steven Shafer

January & February 2015

  • Dr Cheng and Dr. Martin present the MEDICI team’s evidence syntheses and guideline recommendations on implications for surgery services during Ebola outbreaks to members of West Africa and other member states of the GIEESC Working Group at the World Health Organization, Geneva.
  • Dr. Martin is reappointed as a member of the Committee to Evaluate Drugs (CED) at the Ministry of Health & Longterm Care (MOHLTC)

November 2014

  • MEDICI Program Director Dr. Janet Martin attends the Healthcare Innovation Panel with Dr. David Naylor and the Honorable Rona Ambrose, Federal Minister of Health in Toronto on November 25th, 2014

May - August 2014

  • Dr. John-Baptiste supervises three students over the summer (Young Zhou, Sivisan Suntheralingam, (Max) Yuan Qi) on a disinvestment project
  • Amy Newitt (MLIS Candidate) joins the MEDICI team in August 2014

February 2014

  • Dr. (Angel) Fang Zhu joins MEDICI as the Centre's first Postdoctoral Fellow

November 2013

  • MEDICI and the Canadian Agency for Drugs and Technology in Health (CADTH) co-host the Hospital/Regional HTA Symposium on Local Evidence-Based Decisions for Health Care Sustainability in Ottawa November 18th-19th 2013

September 2013

  • Dr. Janet Martin is invited to a Roundtable Meeting on Technological Innovation in Health Care with the Honorable Rona Ambrose, Federal Minister of Health in Toronto on September 9th 2013

Projects

  • Perioperative and anaesthetic related mortality
  • Rapid guideline development for patients with surgical conditions in the context of Ebola Virus Disease
  • Anaesthetic-related maternal mortality in cesarean section 
  • Goal-Directed Therapy
  • Prehabilitation in Total Hip & Knee Arthroplasty
  • TAVI vs. Standard AVR
  • Ischemic Pre-conditioning
  • Orthopedic Surgery: Optimizing Technologies & Techniques
  • Vascular Surgery: Optimizing Technologies & Techniques across Patient Pathway of Care
  • Colloids vs Crystalloids for Acute Care
  • Voluven vs Crystalloids in ICU and Surgery
  • Dexmedetomidine for ICU and Surgery
  • For whom is ECT safe, effective, and cost-effective?
  • Antibiotic prophylaxis

Publications

Wang L, Johnston B, Kaushal A, Cheng D, Zhu F, Martin JKetamine added to morphine or hydromorphone patient-controlled analgesia for acute postoperative pain in adults: a systematic review and meta-analysis of randomized trials. Can J Anaesth. 2015 Dec 10. [Epub ahead of print]

Jasudavisius A, Arellano R, Martin J, McConnell B, Bainbridge D. A systematic review of transthoracic and transesophageal echocardiography in non-cardiac surgery: implications for point-of-care ultrasound education in the operating room. Can J Anaesth. 2015 Oct 30. [Epub ahead of print]

Habbous S, Garg AX, Martin JAppraisal of a redundant report on lanthanum carbonate. Int Urol Nephrol. 2016 Jan;48(1):149-50.

Wang L, Lee M, Zhang Z, Moodie J, Cheng DC, Martin J. Does preoperative rehabilitation for patients planning to undergo joint replacement surgery improve outcomes? A systematic review and meta-analysis of randomized controlled trials. BMJ Open 2016 Jan;6:e009857 

Martin J, Tau G, Cherian MN, Vergel de Dios J, Mills D, Fitzpatrick J, Adu-Krow W, Cheng D. Survey of the capacity for essential surgery and anaesthesia services in Papua New Guinea. BMJ Open. 2015 Dec 16;5(12):e009841. 

Martin J, Cheng D. The real cost of care: focus on value for money, rather than price-tags. Can J Anaesth. 2015 Oct;62(10):1034-41.

Puskas JD, Martin J, Cheng DC, Benussi S, Bonatti JO, Diegeler A, Ferdinand FD, Kieser TM, Lamy A, Mack MJ, Patel NC, Ruel M, Sabik JF 3rd, Yanagawa B, Zamvar V. ISMICS Consensus Conference and Statements of Randomized Controlled Trials of Off-Pump Versus Conventional Coronary Artery Bypass Surgery. Innovations (Phila). 2015 Jul-Aug;10(4):219-29.

Ariyan S, Martin J, Lal A, Cheng D, Borah GL, Chung KC, Conly J, Havlik R, Lee WP, McGrath MH, Pribaz J, Young VL. Antibiotic prophylaxis for preventing surgical-site infection in plastic surgery: an evidence-based consensus conference statement from the American Association of Plastic Surgeons. Plast Reconstr Surg. 2015 Jun;135(6):1723-39.

Bainbridge D, Cheng DC. Early extubation and fast-track management of off-pump cardiac patients in the intensive care unit. Semin Cardiothorac Vasc Anesth. 2015 Jun;19(2):163-8.

Polisena J, Lavis JN, Juzwishin D, McLean-Veysey P, Graham ID, Harstall C, Martin J. Supporting the Use of Health Technology Assessments by Decision-Makers. Healthc Policy. 2015 May;10(4):10-5.

Zhu F, Gomersall CD, Ng SK, Underwood MJ, Lee A. A randomized controlled trial of adaptive support ventilation mode to wean patients after fast-track cardiac valvular surgery. Anesthesiology. 2015 Apr;122(4):832-40.

Rawal S, Barnett C, John-Baptiste A, Thein HH, Krings T, Rinkel GJ. Effectiveness of diagnostic strategies in suspected delayed cerebral ischemia: a decision analysis. Stroke. 2015 Jan;46(1):77-83.

Clarke JTR, Coyle D, Evans G, Martin J, Winquist E. Towards a functional definition of ‘rare disease’ for regulatory agencies and funding agencies. Value in Health 2014;17(8):757-61.

Chin CJ, Sowerby LJ, John-Baptiste A, Rotenberg RW. Reducing otolaryngology surgical inefficiency via assessment of tray redundancy. Journal of Otolaryngology: Head & Neck Surgery 2014; 43(1):46.

Martin J, Cheng D. Perioperative Blood Management: Cardiac Surgery. Waters J (editor). In Perioperative Blood Management: A Physician’s Handbook, 3rd Edition. AABB Press, Bethesda, Maryland, 2014.

Martin J, Fuller J, McConachie I. Fluid Management in ICU, Third Edition, McConachie I (editor) Cambridge University Press, 2014.

Winquist E, Coyle D, Clarke JTR, Coyle D, Evans G, Seager C, Chan W, Martin J. Application of a policy framework for the public funding of drugs for rare diseases. J Gen Intern Med. 2014 Aug 29; Suppl 3:S774-9.

Borger J, Martin J, Cheng D. Book Chapter: Pharmacology of Vasopressors and Inotropes. Textbook of Critical Care. Jaypee Brothers, 2014.

Chui J, Martin J, Cheng D. Acute decompensated heart failure and cardiogenic shock. Textbook fo Critical Care. Jaypee Brothers, 2014.

Martin J, Cheng D. Perioperative Blood Management: Cardiac Surgery. Waters J (editor). In Perioperative Blood Management: A Physician’s Handbook, 3rd Edition. 2014.

Coronado A, Singh H, Martin J, Costella J, Malvankar M, Hodge W. Diagnostic Accuracy of Tele-ophthalmology Alternatives for Diabetic Retinopathy Screening: A Meta-analysis. ARVO Annual Meeting Abstracts, 2014.

Coronado A, Zaric G, Martin J, Malvankar M, Hodge W. Tele-ophthalmology versus in-person examination for diabetic retinopathy screening in Southwestern Ontario: a cost- effectiveness analysis. ARVO Annual Meeting Abstracts, 2014.

Bardou M, Martin J. The increasing need for health-economic assessment in gastrointestinal and liver diseases. Best Pract Res Clin Gastroenterol. 2013;27(6):829-30.

Tanios N, Wagner M, Tony M, Baltussen R, van Til J, Rindress D, Kind P, Goetghebeur MM, Martin J, with the International Task Force on Decision Criteria. Which criteria are considered in health care decisions: Insights from an international survey of policy and clinical decision-makers. Int J Technol Asses Health Care 2013;29(4):456-65.

Martin J, Cheng D. Role of the anesthesiologist in the wider governance of healthcare and health economics. Can J Anesth 2013;60(9):918-928.

Neumann I, Letelier LM, Rada G, Claro JC, Martin J, Howden CW, Yuan Y, Leontiadis GI. Comparison of different regimens of proton pump inhibitors for acute peptic ulcer bleeding. Cochrane Database Syst Rev 2013 Jun 12;6:CD007999.

Coyle D, Bell CM, Clarke JTR, Evans G, Gadhok A, Martin J, Sabharwal M, Winquist E. Application of operations research to funding decisions for treatments with rare disease. Operations Res Health Care Policy. 2013;190:281-294.

Martin J, Wang L, Arango M, Harle C, Cheng DC. Dexmedetomidine for awake fibreoptic intubation: A meta-analysis. Canadian Anesthesiologists Society Annual Meeting Abstracts, 2013, #1653026.

Bainbridge D, Martin J, Arango M, Cheng DAnaesthetic-related mortality in sub-Saharan Africa – Authors’ reply. Lancet. 2013;381(9862):199-200.

Barkun AN, Bhat M, Armstrong D, Dawes M, Donner A, Enns R, Martin J, Moayyedi P, Romagnuolo J, Tugwell P. Effectiveness of disseminating consensus management recommendations for ulcer bleeding: A national cluster randomized trial. CMAJ. 2013 Feb 19;185(3):E156-66

Winquist E, Bell CM, Clarke JT, Evans G, Martin J, Sabharwal M, et al. An evaluation framework for funding drugs for rare diseases. Value in Health 2012 Sep-Oct;15(6):982-6.

Bainbridge D, Martin J, Arango M, Cheng D, for the Evidence-Based Perioperative Clinical Outcomes Research (EPiCOR) Group. Perioperative and anaesthetic-related mortality in developed and developing countries: a systematic review and meta-analysis. Lancet 2012 Sep 22;380(9847):1075-81. 

Martin J, Cheng D. Tranexamic acid for routine use in off-pump coronary artery bypass surgery: evidence base “fait accompli” or further research needed? Anesth Analg. 2012 Aug;115(2)227-30. 

Menkis A, Martin J,Cheng DC, Fitzgerald DC, Freedman JJ, Gao C, Koster A, Mackenzie GS, Murphy GJ, Spiess B, Ad N. Drugs, Devices, Technologies & Techniques for Blood Management in Minimally-Invasive and Conventional Cardiothoracic Surgery: A Consensus Statement from the International Society for Minimally Invasive Cardiothoracic Surgery (ISMICS) 2011. Innovations Technology and Techniques in Cardiothoracic and Vascular Surgery 2012 Jul-Aug;7(4):229-241

Jones D, Barkun AN, Lu Y, Enns R, Sinclair P, Martel M, Gralnek I, Bardou M, Kuipers EJ, Sung J; International Consensus Upper Gastrointestinal Bleeding Conference Group (Agreus L, Armstrong D, Calvet X, Chiba N, Cipolletta L, Cohen H, Ericsson LG, Hunt R, Jensen D, Kaminishi M, Kanwal F, Laine L, Lanas A, Lau J, Leontiadis G, Lundell L, Malfertheiner P, Marshall J, Martin J, Metz D, Moayyedi P, Quenot JP, Rauws E, Romagnuolo J, Rostom A, Spiegel B, Tse F, Van Leerdam M, Van Rensburg C). Conflicts of interest ethics: silencing expertise in the development of international clinical practice guidelines. Ann Intern Med. 2012 Jun 5;156(11):809-816, W-283. 

Greenspoon J, Barkun A, Bardou M, Chiba N, Leontiadis GI, Marshall JK, Metz DC, Romagnuolo J, Sun J; International Consensus Upper Gastrointestinal Bleeding Conference Group (Hunt R, Barkun AN, Bardou M, Kuipers EJ, Sung J, Agreus L, Armstrong D, Calvet X, Chiba N, Cipolletta L, Cohen H, Enns R, Ericsson LG, Gralnek I, Jensen D, Kaminishi M, Kanwal F, Laine L, Lanas A, Lau J, Leontiadis G, Lundell L, Malfertheiner P, Marshall J, Martin J, Metz D, Moayyedi P, Quenot JP, Rauws E, Romagnuolo J, Rostom A, Spiegel B, Tse F, Van Leerdam M, Van Rensburg C). Consensus Guidelines for the Management of Upper Gastrointestinal Bleeding. Clin Gastroenterol Hepatol. 2012 Mar;10(3):234-9.

Alkhemesi N, Martin J, Schlachta C. Cost efficiency of laparoscopic versus open colon surgery in a tertiary care centre. Surg Endosc. 2011 Nov;25(11):3597-604.

Cheng D, Martin J. Evidence-based practice and health technology assessment:a call for anesthesiologists to engage in knowledge translation. Can J Anesth. 2011 Apr; 58(4):354-63. 

Zhang X, Wu Z, Peng X, Wu A, Yue Y, Martin J, Cheng D. Prognosis of diabetic patients undergoing coronary artery bypass surgery compared with nondiabetics: a systematic review and meta-analysis. J Cardiothorac Vasc Anesth. 2011 Apr;25(2):288-98

Wang G, Bainbridge D, Martin J, Cheng D. N-acetylcysteine in cardiac surgery: Do the benefits outweigh the risks? A meta-analytic reappraisal. J Cardiothorac Vasc Anesth. 2011 Apr;25(2):268-75.

Cheng DC, Martin J, Lal A, Diegler A, Folliguet T, Nifong LW, Perrier P, Raanani E, Smith JM, Seeburger J, Falk V. Minimally invasive versus conventional open mitral valve surgery: a meta-analysis and systematic review. Innovations Technology and Techniques in Cardiothoracic and Vascular Surgery 2011 Mar;6(2):84-103.  

Falk V, Cheng D, Martin J, Diegeler A, Folliguet T, Nifong LW, Perrier P, Raanani E, Smith JM, Seeburger J. Minimally invasive versus conventional open mitral valve surgery: A consensus statement of the International Society of Minimally Invasive Coronary Surgery (ISMICS) 2010. Innovations Technology and Techniques in Cardiothoracic and Vascular Surgery 2011 Mar;6(2):66-76.

Sreedharan A, Martin J, Leontiadis GI, Dorward S, Howden CW, Forman D, Moayyedi P. Proton pump inhibitor treatment initiated prior to endoscopic diagnosis in upper gastrointestinal bleeding. Cochrane Database Syst Rev. 2010 Jul;7(7):CD005415.  

Cheng DC, Ad N, Martin J, Berglin EE, Chang BC, Doukas G, Gammie J, Nitta T, Wolf R, Puskas J. Surgical ablation for atrial fibrillation in cardiac surgery: A meta-analysis and systematic review. Innovations Technology and Techniques in Cardiothoracic and Vascular Surgery 2010 Mar;5(2):84-96.

Ad N, Cheng DC, Martin J, Berglin E, Chang BC, Doukas G, Gammie JS, Nitta T, Wolf RK, Puskas JD. Surgical ablation for atrial fibrillation in cardiac surgery: a consensus statement of the International Society of Minimally Invasive Cardiothoracic Surgery (ISMICS) 2009. Innovations Technology and Techniques in Cardiothoracic and Vascular Surgery 2010 Mar;5(2):74-83.

Cheng DC, Martin J, Ferdinand FD, Puskas JD, Diegeler A, Allen, KB. Endoscopic vein-graft harvesting: balancing the risk and benefits. Innovations Technology and Techniques in Cardiothoracic and Vascular Surgery 2010 Mar;5(2):70-73.

Cheng DC, Martin J, Novick R. OPCAB versus on-pump surgery: the beat goes on. Innovations Technology and Techniques in Cardiothoracic and Vascular Surgery 2010 Mar;5(2):67-9.

Bainbridge D, Martin J, Amed-Sabry MH, Craig A, Iglesias I. Orogastric tubes do not improve transesophageal echocardiographic imaging during cardiac surgery: a randomized trial. Can J Anaesth. 2010 Mar;57(3):216-21.

Cheng D, Martin J, Shennib H, Dunning J, Muneretto C, Schueler S, von Segesser, Sergeant P, Turina M, on behalf of the on behalf of the ad hoc EACTS/ ESCVS committee. Endovascular aortic repair versus open surgical repair for descending thoracic aortic disease: a systematic review and meta-analysis of comparative studies. J Am Coll Cardiol. 2010 Mar 9;55(10):986-1001. 

Barkun AN, Bardou M, Kuipers EJ, Sung J, Hunt RH, Martel M, Sinclair P; International Consensus Upper Gastrointestinal Bleeding Conference Group (Hunt R, Barkun AN, Bardou M, Kuipers EJ, Sung J, Agreus L, Armstrong D, Calvet X, Chiba N, Cipolletta L, Cohen H, Enns R, Ericsson LG, Gralnek I, Jensen D, Kaminishi M, Kanwal F, Laine L, Lanas A, Lau J, Leontiadis G, Lundell L, Malfertheiner P, Marshall J, Martin J, Metz D, Moayyedi P, Quenot JP, Rauws E, Romagnuolo J, Rostom A, Spiegel B, Tse F, Van Leerdam M, Van Rensburg C, Jones DJ, Gardeazabal A, Rácz I, Lavigne P, Sinclair P). International consensus recommendations on the management of patients with nonvariceal upper gastrointestinal bleeding. Ann Intern Med. 2010 Jan 19;152(2):101-13.

Bainbridge D, Martin J. Off-pump coronary artery bypass surgery and the kidney. Am J Kidney Dis. 2009 Sep;54(3):395-8. 

Wang G, Bainbridge D, Martin J, Cheng D. The efficacy of intraoperative cell saver during cardiac surgery: a meta-analysis of randomized trials. Anesth Analg. 2009 Aug;109(2):320-30. 

Turina MI, Shennib H, Dunning J, Cheng D, Martin J, Muneretto C, Schueler S, von Segesser, Sergeant PT, on behalf of the ad hoc EACTS/ ESCVS committee. EACTS/ESCVS best practice guidelines for reporting treatment results in the thoracic aorta. Eur J Cardiothorac Surg. 2009 Jun;35(6):927-30. 

Cheng D, Pepper J, Martin J, Stanbridge R, Ferdinand F, Jamieson WR, Stelzer P, Berg G, Sani G. Stentless versus stented bioprosthetic aortic valves: a systematic review and meta-analysis of controlled trials. Innovations Technology and Techniques in Cardiothoracic and Vascular Surgery 2009 Mar;4(2):61-73. 

Pepper J, Cheng D, Stanbridge R, Ferdinand F, Jamieson WR, Stelzer P, Berg G, Sani G, Martin J. Stentless versus stented bioprosthetic aortic valves: a consensus statement of the International Society of Minimally Invasive Cardiothoracic Surgery (ISMICS) 2008. Innovations Technology and Techniques in Cardiothoracic and Vascular Surgery 2009 Mar;4(2):49-60.

Bardou M, Martin J, Barkun A. Intravenous proton pump inhibitors: an evidence-based review of their use in gastrointestinal disorders. Drugs. 2009;69(4):435-48. 

Neumann I, Martin J, Letelier LM, Howden CW, Claro JC, Leontiadis GI. Comparison of different regimens of proton pump inhibitors for acute peptic ulcer bleeding. (Protocol). Cochrane Database Syst Rev. 2009 Oct 7;4:CD007999.

Cheng D, Martin J, Ferdinand M. Endoscopic versus open-vein harvesting. New Engl J Med 2009;361:1908-1909; author reply 1909-10.

Turina MI, Martin J, Cheng D. Reply to Olsson. Eur J Cardiothorac Surg 2009;Oct 8 

Moe S, Wazny L, Martin JOral calcitriol versus oral alfacalcidol for the treatment of secondary hyperparathyroidism in patients receiving hemodialysis: a randomized, crossover trial. Can J Pharmacol 2008 Winter;15(1):e36-43.

Sreedharan A, Martin J, Leontiadis GI, Howden CW, Forman D, Moayyedi P. Proton pump inhibitor treatment initiated prior to endoscopic diagnosis in upper gastrointestinal bleeding. (Protocol). Cochrane Database of Syst Rev. 2008.

Leondiadis GI, Martin J, Moayyadi P. PPI for UGIB. (Protocol). Cochrane Database of Syst Rev. 2008.

Dunning J, Martin JE, Shennib H, Cheng DC. Is it safe to cover the left subclavian artery when placing an endovascular stent in the descending thoracic aorta? Interact Cardiovasc Thorac Surg. 2008 Aug;7(4):690-7.

Bardou M, Martin J. Pantoprazole: from drug metabolism to clinical relevance. Expert Opin Drug Metab Toxicol. 2008 Apr;4(4):471-83.

Martin J, Cheng D, Silverstein M, Bainbridge D, Novick R. Off-pump versus on-pump coronary artery bypass; a cost-effectiveness analysis. Heart Lung Circ 2007;16:S25-S26.

Downey R, Cheng D, Stanbridge S, Schmid R, Kernstine K, Wolf R, Martin J. Video-assisted thoracic surgery for lung cancer resection: A consensus statement of the International Society of Minimally Invasive Cardiothoracic Surgery (ISMICS) 2007. Innovations Technology and Techniques in Cardiothoracic and Vascular Surgery 2007 Nov;2(6):293-302.

Cheng D, Downey RJ, Stanbridge R, Schmid R, Kernstine K, Wolf R, Martin J, et al. Video-assisted thoracic surgery in lung cancer resection: a meta-analysis and systematic review of controlled trials. Innovations Technology and Techniques in Cardiothoracic and Vascular Surgery 2007 Nov;2(6):261-92.

Labinaz M, Ho C, Martin J, Banerjee S, Chen S, Mensinkai S. Meta-analysis of clinical efficacy and bleeding risk with intravenous glycoprotein IIb/IIIa antagonists for percutaneous coronary intervention. Can J Cardiol. 2007 Oct;23(12):963-70.

Bainbridge D, Cheng D, Martin J, Novick R; Evidence-based Peri-operative Clinical Outcomes Research (EPiCOR) Group. Does off-pump or minimally invasive coronary artery bypass reduce mortality, morbidity, and resource utilization when compared with percutaneous coronary intervention? A meta-analysis of randomized trials. J Thorac Cardiovasc Surg 2007 Mar;133(3):623-31. 

Cheng D, Martin J; ISMICS Board of Directors. International Society for Minimally Invasive Cardiothoracic Surgery consensus statements: definitions and terms of reference. Innovations Technology and Techniques in Cardiothoracic and Vascular Surgery 2006 Summer;1(4):175-9.

Bainbridge D, Martin JE, Cheng DC. Patient-controlled versus nurse-controlled analgesia after cardiac surgery – a meta-analysis. Can J Anaesth. 2006 May;53(5):492-9. 

Martin J, Cartabellotta N, Than M, Glasziou P. Building bridges between research and teaching. 3rd International Conference of Evidence-Based Health Care Teachers and Developers. Evid Based Med. 2006;11:7.

Diegeler A, Cheng D, Allen K, Weisel R, Lutter G, Sartori M, Asai T, Aaberge L, Horvath K, Martin J Transmyocardial laser revascularization: a consensus statement of the International Society of Minimally Invasive Cardiothoracic Surgery (ISMICS) 2006. Innovations Technology and Techniques in Cardiothoracic and Vascular Surgery 2006 Winter;1(6):314-322.

Cheng D, Diegeler A, Allen K, Weisel R, Lutter G, Sartori M, Asai T, Aaberge L, Horvath K, Martin J. Transmyocardial laser revascularization: a meta-analysis and systematic review of controlled trials. Innovations Technology and Techniques in Cardiothoracic and Vascular Surgery 2006 Winter;1(6):295-313.

Grindrod K, Patel P, Martin JE. What interventions should pharmacists employ to impact practitioner prescribing practices? Ann Pharmacother. 2006 Sep;40(9):1546-57.

Pollak PT, Wee V, Al-Hazmi A, Martin J, Zarnke KB. The use of amiodarone for in-hospital cardiac arrest at two tertiary care centres. Can J Cardiol. 2006 Mar 1;22(3):199-202.

Bainbridge D, Cheng DC, Martin JE, Novick R; Evidence-Based Perioperative Clinical Outcomes Research (EPiCOR) Group. NSAID-analgesia, pain control and morbidity in cardiothoracic surgery. Can J Anaesth. 2006 Jan;53(1):46-59.

Martin J, Cardiac Anesthesia Pharmacology, Appendix J. In: Cheng DCH, David TE, eds. Perioperative Care in Cardiac Anesthesia and surgery. Lippincott, Williams & Wilkins, Philadelphia: 2006. ISBN 0-7817-5774-6.

Cheng D, Allen K, Cohn W, Connelly M, Edgerton J, Falk V, Martin J, Ohtsuka T, Vitali R. Endoscopic vascular harvest in coronary artery bypass grafting surgery: A meta-analysis of randomized trials and controlled trials. Innovations Technology and Techniques in Cardiothoracic and Vascular Surgery 2005 Winter;1(2):61-74.

Allen K, Cheng D, Cohn W, Connolly M, Edgerton J, Falk V, Martin J, Ohtsuka T, Vitali R. Endoscopic vascular harvest in coronary artery bypass grafting surgery: a consensus statement of the International Society of Minimally Invasive Coronary Surgery (ISMICS) 2005. Innovations Technology and Techniques in Cardiothoracic and Vascular Surgery 2005 Winter;1(2):51-60.

Puskas J, Cheng D, Knight J, Angelini G, DeCannier D, Diegeler A, Dullum M, Martin J, Ochi M, Patel N, Sim E, Trehan N, Zamvar V. Off-pump versus conventional coronary artery bypass grafting: A meta-analysis and consensus statement from the 2004 ISMICS Consensus Conference. Innovations Technology and Techniques in Cardiothoracic and Vascular Surgery 2005 Fall;1(1):3-27.

Cheng DCH, Martin JERaising the bar: a primer on evidence-based decision-making. Seminars in Cardiothoracic and Vascular Anesthesia 2005 Mar;9(1):1-4.

Ho C, Banerjee S, Martin J, Labinaz M, Zarnke K, Chen S, Mensinkai S.  Glycoprotein IIb-IIIa antagonists: review of clinical effectiveness in patients undergoing percutaneous coronary intervention. Ottawa: Canadian Coordinating Office of Health Technology Report, 2005 Jan;49:1-81.

Riley K, Martin J, Wazny L.  Impact of pharmacist-provided education initiation of osteoporosis treatment after fragility fracture. Can Pharm J 2005;138(1):37-43.

Al-Yaseen E, Wells PS, Anderson J, Martin J, Kovacs MJ. The safety of dosing dalteparin based on actual body weight for the treatment of acute venous thromboembolism in obese patients. J Thromb Haemost. 2005 Jan;3(1):100-2.

Summerskill W, Glasziou P, Cartabellotta A, Martin J, Hopayian K, Porzsolt F, Burls A, Osborne J. Sicily statement on evidence-based practice. BMC Medical Education 2005 Jan 5:1:1-14.

Cheng D, Bainbridge D, Martin J, Novick R. Does off-pump coronary artery bypass reduce mortality, morbidity, and resource utilization when compared with conventional coronary artery bypass? A meta-analysis of randomized trials. Anesthesiology 2005 Jan;102(1):188-203. 

Bainbridge D, Cheng D, Martin J. Safety and efficacy of off pump coronary artery bypass surgery versus conventional coronary artery bypass and percutaneous transluminal coronary angioplasty. Seminars in Cardiothoracic and Vascular Anesthesia 2005:9(1):105-111.

Cheng DC, Bainbridge D, Martin JE, Novick RJ. Letter to the Editor – reply. Off-pump coronary artery bypass: randomized trials, real-world experience, clinical relevance, and statistical significance. Underreporting of conversion from off-pump coronary artery bypass surgery. Anesthesiology 2005;103(4):902-3.

Dawes M, Summerskill W, Glasziou P, Cartabellotta A, Martin J, Hopayian K, Porzsolt F, Burls A, Osborne J; Second International Conference of Evidence-Based Health Care Teachers and Developers. Sicily statement on evidence-based practice. BMC Med Educ. 2005 Jan 5;5(1):1-7.

Presentations

Know4Go: An Instrument for decision-making when resources are limited and demands are relentless

Special Presentation by Dr. Janet Martin for the Oxford University Centre for Evidence Based Medicine. 

Ministry of Health of Ontario, monthly presentations and written submission for selected drugs to advise on policy for Ontarians (confidential, drug policy decisions). Committee to Evaluate Drugs (CED) & Executive Officer to the Minister of Health, Ontario Ministry of Health & Long Term Care (MOHLTC  Monthly): Toronto, ON, 2007 to present

Combining Evidence, Economics, Ethics, and Everything Else for Deciding which Technologies and Drugs to pursue to maximize Knowledge Translation. Richard Ivey School of Business, Western University: London, ON, 02/2016

Ebola Virus Disease and other Viral Hemorrhagic Fevers (VHF) in the Context of Surgery: An Evidence-Synthesis and Draft Recommendations. Guideline Development Group, World Health Organization: Geneva, Switzerland, 12/2015

Wicked decisions: real world examples, and how we addressed them in Canada. With Sir Muir Gray, Hellish Decisions, Oxford University: Oxford, United Kingdom, 12/2015

Transcatheter Aortic Valve Implantation vs Conventional Aortic Valve Replacement: An update on the evidence. Los Angeles, CA, 11/2015.

What proportion of anesthesia evidence is valid and relevant? What proportion is wasted? International Evidence-Based Health Care Conference: Taormina, Sicily, 10/2015

Translating evidence into recommendations in the context of rapidly evolving evidence and urgency: experience with Ebola rapid advice guidelines. International Evidence-Based Health Care Conference: Taormina, Sicily, 10/2015

Full Contact Health Technology Assessment: Addressing Difficult Decisions using Know4Go. Health Technology Assessment for Decision-Makers Institute, Toronto Health Economics and Technology Assessment (THETA), University of Toronto: Toronto, ON, 09/2015

Perioperative Anemia: Evidence-Based Management. XL Annual Symposium, Mexican College of Anesthesiologists: Mexico City, Mexico, 07/2015

Perioperative Mortality on a Global Scale: Is it improving? How does it related to Sustainable Development Goals? XL Annual Symposium, Mexican College of Anesthesiologists: Mexico City, Mexico, 07/2015

State of the Evidence in Anesthesia & Perioperative Medicine. Canadian Anesthesiologists Society Annual Meeting: Ottawa, ON, 06/2015

Hospital Based HTA – International Perspectives & Canadian Perspectives. Health Technology Assessment International (HTAi) Annual Symposium: Oslo, Norway, 06/2015

Off-pump coronary artery bypass surgery: Do elderly patients benefit most? 3rd International Symposium: Perioperative Care for Seniors: Prague, Czech Republic, 06/2015

Safe Surgery Checklist: Are the Results Generalizable? A meta-analysis of comparative studies. Euroanaesthesia Congress: Berlin, Germany, 05/2015

Health Technology Assessment, Difficult Decision-Making, and Knowledge Translation – Case Studies from the Canadian & International Setting. Barcelona, Spain, 05/2015

Real world decision-making and evidence assessment. Medical Resident Seminar, Western University: London, ON, 04/2015

The Evidence/Decision-Making Disconnect: Evidence is often not enough. Canadian Agency for Drugs and Technologies in Health Annual Symposium: Saskatoon, SK, 04/2015

Difficult Decision-Making for Rare Diseases: When Evidence, Economics, Ethics and Equity Collide. Canadian Agency for Drugs and Technologies in Health Annual Symposium: Saskatoon, SK, 04/2015

Checklists and Cardiac Surgery: Do the results apply equally to the Developed as the Developing World, within and outside the clinical trial setting? 37th SCA and ICCVA Annual Meeting: Washington, DC, 04/2015

Fluid Management: Does the choice of crystalloid matter? 37th SCA and ICCVA Annual Meeting: Washington, DC, 04/2015

State of the Evidence in Anesthesia & Perioperative Medicine. International Anesthesia Research Society Annual Meeting (IARS): Honolulu, HI, 03/2015

Ebola & evidence: does the weight of the evidence reflect the weight of the problem? Rapid Advice Guideline Panel, World Health Organization (WHO): Geneva, Switzerland, 02/2015

Know4Go: combining evidence, economics, ethics, and ‘everything else’ to decide what to take up versus what to forgo in healthcare. Presentation to Dr. Bob Bell, Deputy Minister of Health and Long Term Care, Ontario Ministry of Health: Ontario, 02/2015.

Statistical Tips and Tricks to Discern Evidence:  Managing Bias and Spin. 18th Annual Conference of the Indian Association of Cardiovascular Anaesthesiologists (IACTA): Jaipur, India, 02/2015

Dexmedetomidine and its role in ICU and Perioperative Medicine. 18th Annual Conference of the Indian Association of Cardiovascular Anaesthesiologists (IACTA): Jaipur, India, 02/2015

Erythropoietin and other blood conservation techniques in cardiac surgery: an evidence-based analysis. 33rd Annual International Symposium: Clinical Update in Anesthesiology, Surgery and Perioperative Medicine: Saint Kitts, Saint Kitts and Nevis, 01/2015

Ebola – defining & GRADE’ing the evidence. Ebola Guidelines Planning Committee World Health Organization (WHO): Geneva, Switzerland, 12/2014

Robotic Surgery & Cost-Effectiveness. Surgery Services Research Committee: London, ON, 12/2014

ECT for Mental Health Patients: Should we expand our services in London and region? Regional Mental Health Services: London, ON, 12/2014

High throughput Hospital Platform for Pragmatic RCTs of common interventions and policies: A vision but not yet a plan. Trials within Cohorts (TWICs) Symposium, London School of Hygiene & Tropical Medicine: London, United Kingdom, 11/2014

Evidence Based Decision Making and Knowledge Translation in Health Technology Assessment (EBDM, KT& HTA). 14th International Congress on Cardiovascular Anesthesia and European European Association of Cardiothoracic Anaesthesiologists (ICCVA-EACTA): Florence, Italy, 09/2014

Pro/Con Debate: I can live without colloids. 14th International Congress on Cardiovascular Anesthesia and European European Association of Cardiothoracic Anaesthesiologists (ICCVA-EACTA): Florence, Italy, 09/2014

How to use evidence in clinical decision-making. Medical Resident Seminar, Western University: London, ON, 09/2014

Health Economics: Can we afford to ignore it? 14th International Congress on Cardiovascular Anesthesia and European Association of Cardiothoracic Anaesthesiologists (ICCVA-EACTA): Florence, Italy, 09/2014

Health technology assessment & Know4Go. Critical Care Boot Camp, Western University: London, ON, 07/2014

Evidence Based Decision Making and Knowledge Translation in Health Technology Assessment. Canadian Anesthesiology Society (CAS) Annual Meeting: St. John’s, NFLD, 06/2014

Multi-criteria decision-making across the continuum of decision: feedback and reflection from the field. Health Technology Assessment International (HTAi): Washington, DC, 06/2014

Evidence in Context: Hospital-Based HTA adds Significantly to Arms-Length HTA in Canada. Health Technology Assessment International (HTAi): Washington, DC, 06/2014

Multicriteria Decision-Making: Reflections from the perspective of the Policymaker in the MoH and the Hospital Settings. Health Technology Assessment International (HTAi): Washington, DC, 06/2014

Hospital Based HTA: Building a network in Canada with International Partners. Health Technology Assessment International (HTAi): Washington, DC, 06/2014

Disinvestment: Proposing a taxonomy for assessment. De-Adoption of Ineffective or Untested Clinical Practices: KT Canada Annual Scientific Meeting: Quebec City, QC, 06/2014

Decision-making frameworks for HTA: lessons from the real world. MSc HTA students, Health Policy, Management & Evaluation (HPME), University of Toronto: Toronto, ON, 05/2014

Evidence based decision-making and knowledge translation in health technology assessment. IARS Education Symposium: Montreal, QC, 05/2014

Real world cases - let’s put you in the decision-maker seat. Medical Resident Seminar, Western University: London, ON, 05/2014

HTA & regulatory decision-makers: opportunities for innovation. Canadian Agency for Drugs and Technologies in Health Annual Symposium: Gatineau, QC. 04/2014

Decision-Making: Combining Evidence + Ethics + “Everything else” in the Real World Setting. Vanderbilt University: Nashville, TN, USA, 02/2014

Bias in Decision-Making & Strategies to Overcome. Vanderbilt University: Nashville, TN, USA, 02/2014

ECT: Should we increase, decrease, or stay the same? LHSC & SJHC series on ECT, Regional Mental Health Unit: London, ON, 02/2014

Voluven: A meta-analysis & recommendations for practice. 32nd Annual Symposium: Clinical Update in Anesthesiology, Surgery and Perioperative Medicine: Atlantis, Bahamas, 01/2014

Erythropoeitin: An updated meta-analysis for Cardiac Surgery. 32nd Annual Symposium: Clinical Update in Anesthesiology, Surgery and Perioperative Medicine: Atlantis, Bahamas, 01/2014

Hospital-Based HTA: a tale of two hospitals. Inaugural Pan-Canadian Hospital-Based Health Technology Assessment Meeting: Ottawa, ON, 11/2013

Establishing a network of hospital/regional HTA in Canada. Inaugural Pan-Canadian Hospital-Based Health Technology Assessment Meeting: Ottawa, ON, 11/2013

Evidence based decision making & health technology assessment for anesthesia & surgery: building a Centre of Excellence. Special Panel & Poster Presentation, Ministry of Health and Long-Term Care AFP Innovation Showcase: Toronto, ON, 11/2013

Introduction to Hospital/Regional HTA. 2nd Annual Symposium on Hospital-Based HTA: Ottawa, ON, 11/2013

Evidence-based medicine & knowledge translation. World Congress of Surgery & Obstetric Anesthesia, WHO GIEESC: Port of Spain, Trinidad & Tobago, 11/2013

Establishing A Network of Hospital/Regional HTA in Canada. Inaugural Pan-Canadian Hospital-Based Health Technology Assessment Meeting: Ottawa, ON, 11/2013

Hospital/Regional-Based HTA: Establishing a Network in Canada. 2nd Annual Symposium on Hospital-Based HTA: Ottawa, ON, 11/2013

Evidence-Based Medicine & Knowledge Translation. Clinical Update in Anesthesiology & Perioperative Medicine: Las Vegas, NV, 11/2013

Evidence-Based Decision-Making and Knowledge Translation in Perioperative Medicine. Update in Clinical Anesthesiology, Surgery and Perioperative Medicine (Co-chair & presenter): Las Vegas, NV, 10/2013

Colloids vs Crystalloids: An Evidence-Based Review. Asian Society of Cardiac Anesthesia (ASCA): Singapore, Sl., 10/2013

Inhaled Nitric Oxide: An Updated Meta-Analysis. Asian Society of Cardiac Anesthesia (ASCA): Singapore, Sl., 10/2013

Evidence-based decision-making, health technology assessment, and knowledge translation. Biennial WHO GIEESC Meeting, World Congress of Surgery, Obstetrics, Trauma and Anesthesia: Port of Spain, Trinidad & Tobago, 10/2013

Perioperative mortality: trends in developing and developed countries. Biennial WHO GIEESC Meeting, World Congress of Surgery, Obstetrics, Trauma and Anesthesia: Port of Spain, Trinidad & Tobago, 10/2013

Getting from Evidence to Action using Know4Go in the Hospital Setting: HTA in the Real World. McGill University Hospitals: Montreal, QC, 10/2013

Bias in Decision-Making: Tips & Tricks to Overcome it Using Evidence-Informed Decision-Making. Queen’s University Medical School, CORE Rounds: Kingston, ON, 09/2013

Evidence and knowledge translation in the wild wooly world of clinical practice. Queen’s University Medical School: Kingston, ON, 09/2013

Study design. Medical Fellows Education Rounds, Western University: London, ON, 09/2013

Evidence and knowledge translation in the wild wooly world of clinical practice. Queen’s University Medical School: Kingston, ON, 09/2013

HES in Surgery and ICU: Is it time to abandon ship? Grand Rounds, Kingston General Hospital: Kingston, ON, 09/2013

Full Contact HTA! How Hospital Based Local HTA adds to Arms-Length HTA. Health Technology Assessment Institute, THETA, Croft Chapter House, University of Toronto: Toronto, ON, 06/2013

Introduction to Hospital-Based HTA (HB-HTA). Health Technology Assessment International (HTAi) 10th Annual Meeting: Seoul, South Korea, 06/2013

Hospital & Regional HTA: Managing the Interface to Optimize KT. Health Technology Assessment International (HTAi), 10th Annual Meeting: Seoul, South Korea, 06/2013

Off-Pump Bypass Surgery – Who benefits from innovation? Society for Cardiothoracic Anesthesia (SCA) Annual Meeting: Miami, FL, 05/2013

OPCAB: Bringing evidence (& uncertainties) into recommendations. Society of Minimally Invasive Cardiothoracic Surgery, Consensus Conference: Dublin, Ireland, 05/2013

OPCAB vs CCAB: Regressions and Subgroups. Society of Minimally Invasive Cardiothoracic Surgery, Consensus Conference: Dublin, Ireland, 05/2013

OPCAB vs CCAB: Systematic Review & Meta-Analysis, Part I. Society of Minimally Invasive Cardiothoracic Surgery, Consensus Conference: Dublin, Ireland, 05/2013

OPCAB vs CCAB: Systematic Review & Meta-Analysis, Part II. Society of Minimally Invasive Cardiothoracic Surgery, Consensus Conference: Dublin, Ireland, 05/2013

Health Technology Assessment & Knowledge Translation: Where theory intersects with reality. University of Barcelona, Graduate School of Economics: Barcelona, Spain, 05/2013

Know4Go: Bringing Evidence, Economics, Ethics and ‘Everything Else’ into Health Technology Decision-Making. University of Barcelona, Graduate School of Economics: Barcelona, Spain, 05/2013

OPCAB vs CCAB: Applying your knowledge to a real world case. University of Barcelona, Graduate School of Economics: Barcelona, Spain, 05/2013

Bias & Error in Decision-Making. University of Barcelona, Graduate School of Economics: Barcelona, Spain, 05/2013

Off-Pump vs On-Pump Bypass Surgery: An updated meta-analysis. Seoul National University (SNU): Seoul, South Korea, 05/2013

Evidence-Based Decision-Making & Knowledge Translation. Invited Workshop for the International Anesthesia Research Society (IARS) Annual Meeting: San Diego, USA, 05/2013

Barriers to uptake of HTA. Canadian Agency for Drugs and Technologies in Health Annual Symposium: St. John’s, NFLD, 05/2013

Quantifying the opportunity cost. Invited Session, Canadian Agency for Drugs and Technologies in Health Annual Symposium: St. John’s, NFLD, 05/2013

International collaboration for Hospital HTA. Invitation to collaborate in Hospital HTA with Seoul Hospital and Korean Ministry of Health: Seoul, South Korea, 04/2013

Knowledge Translation in Mental Health: Defining our Priorities & Measuring our Impact. Regional Mental Health Grand Rounds: London, ON, 03/2013

Colloids vs Crystalloids – What should be the role of Voluven in Surgery and Critical Care? A Systematic Review & Economic Analysis. Citywide Critical Care Grand Rounds: London, ON, 02/2013

Colloids vs Crystalloids – What should be the role of Voluven in Surgery and Critical Care? A Systematic Review & Economic Analysis. Pharmacy & Therapeutics Committee, St Josephs Health Care London: London, ON, 02/2013

Evidence-Based Decision-Making & Health Technology Assessment. Update in Clinical Anesthesia: Curacao, NL., 01/2013

Off-Pump Bypass Surgery: An Update. Update in Clinical Anesthesia: Curacao, NL., 01/2013

Colloids vs Crystalloids – What should be the role of Voluven in Surgery and Critical Care? A Systematic Review & Economic Analysis. Drug & Therapeutics Committee, London Health Sciences Centre: London, ON, 01/2013

Colloids vs Crystalloids – What should be the role of Voluven in Surgery and Critical Care? A Systematic Review & Economic Analysis. Citywide Anesthesia Grand Rounds: London, ON, 01/2013

Update on HTA in Canada. Invited Speaker Presentation. Health Canada Pan-Canadian HTA Collaborative: Ottawa, ON, 11/2012

Dexmedetomidine for Awake Fibreoptic Intubation: A Meta-Analysis. Drug & Therapeutics Committee: London, ON, 10/2012

Dexmedetomidine for Craniotomy: A Meta-Analysis. Drug & Therapeutics Committee: London, ON, 10/2012

Dexmedetomidine for Monitored Anesthesia Care and Procedural Sedation: A systematic review. Drug & Therapeutics Committee: London, ON, 10/2012

Creating the Business Case Using an Evidence Based Approach to Innovation Adoption and Commercialization in Global Health Systems. Leaders in Innovation: Accelerating Genomic Innovation in Life-science Enterprises (AGILE). International Centre for Health Innovation, Executive Development Program 2012, Western University: London, ON, 10/2012

Drug shortages. Ontario Medical Association Conference: London, ON, 09/2012

Colloids vs Crystalloids. Asian Society for Cardiothoracic Anesthesia (ASCA): Beijing, China, 08/2012

Off-Pump Bypass Surgery. Asian Society for Cardiothoracic Anesthesia (ASCA): Beijing, China, 08/2012

How to Interpret Meta-Analysis. 7th Biennial Cardiopulmonary Bypass Conference: Kuching, Malaysia, 06/2012

Colloids vs Crystalloids: Evidence-Based Review for Surgery & Critical Care. 7th Biennial Cardiopulmonary Bypass Conference: Kuching, Malaysia, 06/2012

Health Technology Assessment at the Pace of Decision Making. Special Presentation for International MSc(HTA) students, University of Toronto: Toronto, ON, 05/2012

Evidence-Based Medicine Workshop. International Anesthesia Research Society (IARS) Annual Meeting: Boston, MAS, O5/2012

Anatomy of decision-making & a post-mortem of policy-making: assessing multiple criteria with validity, relevance, consistency and transparency (Know4Go). Ontario Ministry of Health & Long Term Care: Toronto, ON, 05/2012

Dexmedetomidine: A Series of Meta-Analyses to Inform Decision-Making in ICU. LHSC Drug & Therapeutics Committee: London, ON, 05/2012

Ketamine: A meta-analysis and meta-regression to inform decision-making for perioperative use. LHSC Drug & Therapeutics Committee: London, ON, 05/2012

Ketamine: A systematic review of use in palliative care. Drug & Therapeutics Committee, London Health Sciences Centre: London, ON, 04/2012

Ketamine: A systematic review and dose-response analysis for acute post-operative pain. Is it opioid-sparing? Drug & Therapeutics Committee, London Health Sciences Centre: London, ON, 04/2012

Dexmedetomidine: A meta-analysis of evidence for prolonged sedation in ICU (adults and pediatrics). Drug & Therapeutics Committee: London, ON, 04/2012

Top 10 BIG IDEAS for Global Health Technology Assessment. Canadian Agency for Drugs and Technologies in Health Annual Symposium: Ottawa, ON, 04/2012

How to Interpret Meta-Analysis. Education Session for visiting Anesthesia Fellows: London, ON, 04/2012

HTA & Know4Go: Examples of decision-making in Hospital Setting. IVEY School of Business, Health Strategy MBA Class: London, ON, 03/2012

Open versus Laparoscopic Colectomy for Patients with Endoscopically Unresectable Polyps: A Comparative Cost Analysis. SAGES Meeting: San Diego, CA, 03/2012

Antibiotic Prophylaxis in Plastic Surgery: Meta-Analysis of Controlled Studies. American Society of Plastic Surgeons: Ft. Myers, FL, 02/2012

Health Technology Assessment: Topics in Cardiac Anesthesia. 15th Annual Conference of the Indian Association of Cardiothoracic & Vascular Anesthesia: New Delhi, India, 02/2012

Inhaled Nitric Oxide for Acute Right Heart Failure: Where is the Evidence? 15th Annual Conference of the Indian Association of Cardiothoracic & Vascular Anesthesia: New Delhi, India, 02/2012

Do you know Know4Go? Full contact HTA in the real world. Toronto Health Economics and Technology Assessment (THETA) Rounds, University of Toronto: Toronto, ON, 12/2011

Bringing Evidence to Life: Why Evidence Alone is Not Enough. Knowledge Synthesis/Knowledge Translation Day, Schulich School of Medicine & Dentistry, University of Western Ontario: London, ON, 11/2011

Medical Evidence, Decision Integrity, Clinical Impact (MEDICI). Epidemiology & Biostatistics Department, Faculty Committee: London, ON, 10/2011

Medical Evidence, Decision Integrity, Clinical Impact (MEDICI). Presentation to: Senior Leadership Committee (SLC) at Schulich Medicine & Dentistry, Senior Leadership Team of SJHC and LHSC: London, ON, 07/2011

Perioperative Blood Management in Cardiac Surgery – Consensus Statements 2011. ISMICS Expert Consensus Conference, Panel Contributor: Washington, DC, 06/2011

Measuring Value of Medical Innovation: Value vs Cost. Medical Technology Innovation ICHIL Ivey School of Business Symposium: London, ON, 06/2011

Medical Decision Making: Evidence is Essential, but Insufficient. HPME, University of Toronto: Toronto, ON, 05/2011

Medical Decision Making: Using Evidence, and Dealing with its Imperfections. HPME, University of Toronto: Toronto, ON, 05/2011

Know4Go: Using Evidence, Ethics, Economics & Everything Else in Decision Making. HPME, University of Toronto: Toronto, ON, 05/2011

Transcatheter Aortic Valve Intervention: A Case Study for Improving Hospital Level Decision Making. HPME, University of Toronto: Toronto, ON, 05/2011

Applying HTA to Decision-Making in Ontario:  Macro, Meso, Micro Levels. University of Toronto: Toronto, ON, 05/2011

Multi-criteria decision analysis for HTA using Know4Go. Canadian Agency for Drugs and Technologies in Health Annual Symposium: Vancouver, BC, 04/11

Evidence is Essential, but Insufficient: Combining Evidence, Economics and the SLEEPERs to address Wicked Decisions in Healthcare. Health Technology Assessment and Management (HTA&M), Health Canada: Ottawa, ON, 04/11

Using Know4Go to improve decision-making at the macro level. Invited presentation to the Executive of the BC Ministry of Health: Victoria, BC, 04/2011

Using Know4Go to improve decision-making locally & regionally. Invited presentation to the BC Ministries (Health, Environment, Social Programs), Health Policy Rounds: Victoria, BC, 04/2011

Know4Go: Using Evidence, Ethics, Economics & Everything Else in Decision Making. Health Care Reform & Comparative Effectiveness Review, Rochester University: Rochester, NY, 04/2011

Contextualization in HTA: Is there a “science” – The Hospital Perspective. Canadian Agency for Drugs and Technologies in Health Annual Symposium on Health Technology Assessment: Vancouver, BC, 04/2011

Evidence-Based Decision Making & Knowledge Translation. City-wide Grand Rounds, Department of Anesthesia & Perioperative Medicine: London, ON, 03/2011

Perioperative Blood Management in Cardiac Surgery – Consensus Statements 2011. ISMICS Expert Consensus Conference, Panel Contributor: Washington, DC, 06/2011

Know4Go & EPiCOR: Evidence-Based Perioperative Drug Therapy – Getting Evidence into Policy & Practice. Invited Panel Presentation, Ministry of Health and Long-Term Care AFP Innovation Fund Provincial Oversight Committee Showcase: Toronto, ON, 11/2010

Know4Go: Using Evidence, Ethics & Economics in Decision-Making. Invited Presentation to Ministers and Health Policy Analysts of Health Canada (in consideration of a renewed Health Technology Management Strategy, moving beyond HTS 1.0): Ottawa, ON, 11/2010

Health Technology Assessment & Management: A Coordinated Strategy for Canada. Invited Presentation to Ministers and Health Policy Analysts of Health Canada (in consideration of a renewed Health Technology Management Strategy, moving beyond HTS 1.0): Ottawa, ON, 11/2010

High Impact HTA: Assessing Evidence, Ethics, Economics in Context within Constrained Time Limits using Know4Go. International Conference of Cardiovascular & Vascular Anesthesia (ICCVA): Beijing, China, 09/2010

HTA & Innovation in Canada: From Local to Provincial to National Impact. Venice Summer School in HTA: Venice, Italy, 07/2010

Know4Go: A Decision-Making Approach to Systematically Incorporate Evidence, Ethics, Economics, (& Everything Else). Canadian Association for Population Therapeutics (CAPT) Annual Symposium: Toronto, ON, 03/2010

Coping with a paucity of data: an evaluation framework for rare diseases. Canadian Association for Population Therapeutics (CAPT) Annual Symposium, contribution to presentation by Chaim Bell: Toronto, ON, 03/2010

Know4Go: A Decision-Making Instrument to Incorporate Evidence, Ethics, Economics, (& Everything Else). Invited Honarary Lecture, Systematic Reviews Module, Masters Program in EBHC, Oxford University: Oxford, United Kingdom, 01/2010

Inhaled Nitric Oxide: Effective & Worth it? Or, unnecessary cost pressure? European Work Group for Intensive Care Medicine: Budapest, Hungary, 11/2009

Patient Collaborative Evidence-Based Decision Making: A Randomized Controlled Trial. 5th International Conference of Evidence Based Health Care: Taormina, Italy, 10/2009

Making Difficult Decisions: Know4Go. Workshop for the 5th International Conference of Evidence Based Health Care: Taormina, Italy, 10/2009

Drug Therapies in Hospital: Advancing the Patient Safety Agenda. 3rd International Patient Safety Congress: Istanbul, Turkey, 06/2009

Is moxifloxacin better than other antibiotics for patients hospitalized with community acquired pneumonia? 26th International Congress of Chemotherapy & Infection: Toronto, ON, 06/2009

Is linezolid better than other antibiotics for VRE and MRSA? 26th International Congress of Chemotherapy & Infection: Toronto, ON, 06/2009

Making Difficult Decisions when the Stakes are High: Drug Formularies & Hospital Health Technologies. University of Western Ontario. Invited Speaker, Showcase Health Policy at Western, Ivey Business School: London, ON, 05/2009

Hospitals & technologies: the need for health technology decision-making at the speed of decision-making. 2009 Annual CADTH Symposium: Evidence, Decisions, Outcomes: Optimizing the Use of Drugs and Health Technologies: Ottawa, ON, 04/2009

Know4Go for Diagnostics and Imaging. VP and Senior Leadership Team, London Health Sciences Centre: London, ON, 03/2009

Know4Go: Update for LHSC. Business Practices Council: London, ON, 03/2009

Evidence Based Practice: A Primer for Pharmacists. University of Waterloo, Special Seminar: Waterloo, ON, 03/2009

Evidence Based Practice. University of Waterloo, EBP Course for Undergraduate Pharmacy Students: Waterloo, ON, 02/2009

Knowledge Translation: A Primer for Front-Line Pharmacists. Annual Pharmacy Professional Practice (PPC): Toronto, ON, 01/2009

Know4Go: Update for LHSC. Presentation to the Surgical Services HTA Board: London, ON, 11/2008

TEVAR Meta-Analysis: An Update. Presentation to the Consensus Panel of the European Association of Cardiothoracic Surgery: Zurich, Switzerland, 10/2008

PPI: What dose is optimal? A meta-regression. Presentation to the Consensus Panel at the ICONS PPI International Consensus Conference: Vienna, Austria, 10/2008

Opportunities for Inter-China-Canada Research Collaboration in EBM and HTA. Presentation to the Senior Leadership of Fuwai Hospital, Department of Surgery and Anesthesia: Beijing, China, 10/2008

Issues in Meta-Analysis: A Case Example using OPCAB vs CCAB. Workshop in Evidence Based Medicine, International Congress of Cardiothoracic & Vascular Anesthesia (ICCVA): Berlin, Germany, 09/2008

Know4Go: An Update. Senior Leadership Team, London Health Sciences Centre: London, ON, 05/2008

How We Know What Isn’t So: Effective and Efficient Decision Making in a Complex World. Anesthesia Research Day, University of Western Ontario: London, ON, 05/2008

Meta-Analysis of Stentless versus Stented Valves for Aortic Valve Replacement. International Society for Minimally Invasive Cardiovascular Surgery (ISMICS): Windsor, United Kingdom, 04/2008

Meta-Analysis of TEVAR versus Open Surgery for Thoracic Aortic Aneurysm. European Association of Cardiothoracic Surgery (EACTS) Annual Meeting: Windsor, United Kingdom, 04/2008

Evidence-Based Decision-Making: Lessons from the Policy Front. Evidence Based Medicine Symposium, Turkish Centre for EBM: Antalya, Turkey, 03/2008

Tools, tips & tricks for EBM: Resources relevant for the Practitioner to the CEO. Evidence Based Medicine Symposium, Turkish Centre for EBM: Antalya, Turkey, 03/2008

The Role of Innovation for Patient Safety: Evidence and Other Paradigms. 2nd  International Patient Safety Congress: Antalya, Turkey, 03/2008

Natural Health Products and Herbal Medicine: The Evidence Base. 2nd  International Patient Safety Congress: Antalya, Turkey, 03/2008

Meta-Analysis of TEVAR versus Open Surgery for Thoracic Aortic Aneurysm. European Association of Cardiothoracic Surgery (EACTS) Board Meeting: Zurich, Switzerland, 01/2008

Know4Go: Beyond Evidence-Based Decision-Making. 4th International Conference for Teachers and Developers of Evidence Based Health Care: Taormina, Italy, 11/2007

Know4Go: Application at the Hospital Level. Senior Medical Leaders Meeting: London, ON, 10/2007

Evidence-Based Decision-Making in the Real World. Teaching Evidence Based Medicine, St Hugh’s College, Oxford University, Workshop Presentation: Oxford, United Kingdom, 09/2007

Know4Go: Decision-Making that Brings Evidence, Ethics, Politics into Accountability. Canadian Council for Health Services Executives (CCHSE): Toronto, ON, 06/2007

Evidence, economics, and ethics for tough decision-making. Dalhousie University CME: Moncton, NB, 05/2007

Video-Assisted Thoracotomy: A Meta-Analysis & Systematic Review. International Society for Minimally Invasive Cardiothoracic Surgery (ISMICS), Invitational Evidence-Based Consensus Conference: Paris, France, 04/2007

Political and Ethical Issues in HTA Decision Making. 3rd Annual Invitational Symposium, Canadian Agency for Drugs and Technologies in Health: Ottawa, ON, 04/2007

Expensive Drugs for Rare Diseases: Stories from the Coal-Face. 3rd Annual Invitational Symposium, Canadian Agency for Drugs and Technologies in Health: Ottawa, ON, 04/2007

Cost-Utility Analysis of Off-Pump vs On-Pump CABG. Annual Lawson Health & Sister Doyle Research Day: London, ON, 03/2007

HTA & EBM Decision Making. Putting Evidence into Practice (PEP) Program: Edmonton, AB, 11/2006

Off-pump versus On-Pump Cardiac Surgery: An Economic Analysis. International Society of Minimally Invasive Surgery: Cairns, Australia, 10/2006

Know4Go:  Inhaled Nitric Oxide and Drug Eluting Stents. Director’s Council, London Health Sciences Centre: London, ON, 10/2006

Know4Go: Putting HTA & EBM into Practice. Director’s Council, London Health Sciences Centre: London, ON, 10/2006

Proton Pump Inhibitors: What role in the hospital setting? Therapeutics in Action, Regional Pharmacy Conference: London, ON, 10/2006

MAZE Procedure: A Meta-Analysis of Clinical and Economic Outcomes. Canadian Anesthesiologists’ Society, Annual Meeting: Toronto, ON, 06/2006

How to Interpret Meta-Analysis & Systematic Review. International Society of Minimally Invasive Surgery, Consensus Conference: London, United Kingdom, 05/2006

Shoot First, Ask Questions Later. What to do with imperfect evidence? How to Teach Evidence Based Practice, Small Group Workshop Presentation: Oxford, United Kingdom, 09/2006

Know4Go! Evaluating the Uptake and Impact of Hospital HTA. AETMIS, McGill University: Montreal, QC, 03/2006

Forest Plots: A Primer. Canadian Research in Colloids Meeting: Toronto, ON, 03/2006

Care as Charity? What are our obligations to provide ‘unfunded’ treatment? Bioethics Forum, London Health Sciences Centre: London, ON, 02/2006

PDQ Critical Evaluation of Evidence Syntheses. London Health Sciences Centre: London, ON, 01/2006

PDQ Critical Evaluation of Randomized Trials. London Health Sciences Centre: London, ON, 01/2006

Evidence-Based Decision Making. . . on the fly! London Health Sciences Centre: London, ON, 01/2006

Changing Prescribers’ Practice: What Works? An Evidence-Based Review for Pharmacists. Professional Practice Conference, Canadian Society of Hospital Pharmacists: Toronto, ON, 01/2006

Evidence-Based Decision-Making in Action: Experience in a Canadian Hospital. Third Biennial Sicily Conference for Teachers and Developers of Evidence Based Health Care: Taormina, Italy, 11/2005

Anemia Workshop for Practitioners. University of Western Ontario, Continuing Medical Education: London, ON, 06/2005

Patient Controlled Anesthesia vs Nurse-Controlled Analgesia: A Meta-Analysis. Health Technology Assessment International, Annual Meeting: Rome, Italy, 06/2005

Know4Go: Using Evidence, Economics, Evidence and Everything Else in Real World Health Technology Assessment. 2005 Annual Canadian Coordinating Office of Health Technology Assessment, CCOHTA (now called CADTH): Ottawa, ON, 04/2005

Building Capacity in Hospital HTA: Project Know4Go. Relevance, Quality, Capacity. Current Issues for Health Technology Assessment in Canada, CCOHTA: Ottawa, ON, 04/2005

Courses & Workshops

Graduate Level Courses

CLINICAL EPIDEMIOLOGY 9562A, Masters in Epidemiology, Western University (Dr. Janet Martin)

HEALTH ECONOMICS 9014U, Masters in Public Health, Western University (Dr. Ava John-Baptiste)

HTA & DECISION-MAKING, International Masters in Health Technology Assessment, School of Economics, University of Barcelona (Dr. Janet Martin)  

Workshops

MEDICI provdes workshops on the following topics:

  • Know4Go: a framework for decision-making when resources are limited and options are many
  • Health Economics
  • Hospital-Based HTA
  • Statistics for the Terrified
  • Bias & Spin: Tips and Tricks for Discerning the Literature
  • Evidence-Based Decision-Making, HTA & Kowledge Translation

Previous workshops include:

  • Clinical Trial Design
  • Interpreting Medical Literature for Decision Makers
  • How to Teach Evidence-Based Medicine 
  • Evidence-Based Guidelines Development

Awards & Recognitions

Dr. Janet Martin: Teaching Excellence Award, Department of Epidemiology & Biostatistics, Schulich School of Medicine & Dentistry, 2012

MEDICI: Best Poster Award, Ketamine added to Morphine PCA: A Meta-Analysis of Randomized Trials: Canadian Anesthesiologists Society Annual Meeting, 2013 

MEDICI: Best poster award, 3rd Prize, Off-pump versus on-pump bypass surgery: Do the elderly benefit most? A meta-regression: Clinical Update in Anesthesia & Perioperative Medicine, 2011

History

In 2011 with the support of the Schulich School of Medicine and Dentistry (SSMD), London Health Sciences Centre (LHSC) and Lawson Research, we are establishing a MEDICI Centre (Medical Evidence, Decision Integrity, Clinical Impact) to be the first hospital-based, evidence-based health technology assessment program in Ontario. This program will seek to involve other hospitals and the Ministry of Health and Long-term Care (MOHLTC) to build network capacity to answer high priority healthcare questions in a timely, transparent and accountable manner.

Evidence-based Decision Making and Health Technology Assessment (HTA) workshops and courses at the Schulich School of Medicine and Dentistry and cross-faculty within Western, will be established and likewise, a network with an international consortium of universities to provide an International MSc (HTA) program.

The Network will generate new hypotheses for innovative research in applied decision-making and knowledge translation techniques to address key evidence gaps and translation gaps related to the constant tension between available technologies and resources in healthcare.

Team

  • Janet Martin, PharmD, MSc(HTA&M), Program Director
  • Davy Cheng, MD, FRCPC, Medical Director
  • Ava John-Baptiste, PhD, Health Economist
  • Jessica Moodie, MLIS, Program Coordinator & Information Specialist
  • Amy Newitt, MLIS, Research Assistant & Information Specialist
  • Current Trainees:
    • Angel (Fang) Zhu, MD, PhD, Postdoctoral Fellow
    • Jennifer Vergel de Dios, MD, MPH, Research Fellow
    • Jingyi Li, MD, PhD, Postdoctoral Fellow
    • Junsong Gong, MD, PhD, Postdoctoral Fellow
    • Matthew Chong, MD, PGY2
    • Rohin Krishnan, MSc Student
    • Riaz Qureshi, MSc Student
    • Atoosa Enzevai, MD, Critical Care Fellow

Media

Systematic review and meta-analysis from the MEDICI Centre on perioperative and anaesthetic-related mortality in developed and developing countries recieves extensive media coverage: 

Know4Go profiled in various sources and media outlets:

Drs. Cheng and Martin invited to WHO's 10th Anniversary of GIEESC

Dr. Janet Martin to join international scientific program planning committee for upcoming EBHC

Dept Chair & Chief Dr. Davy Cheng receives prestigious 2014 CSPE Excellence in Medical Leadership Award

Dr. Davy Cheng is elected to German Society of Anaesthesiology and Intensive Care Medicine (DGAI) as 2014's honorary member

MEDICI's Safe Surgery Checklist study is recognized in the media

MEDICI's systematic review and meta-analysis of endovascular aortic repair versus open surgical repair for descending thoracic aortic disease is featured on the Doctor's Channel Daily Newscast