(Cross-appointed with the Department of Psychiatry)
Ph.D. University of Western Ontario
M.Sc. University of Western Ontario
M.B.B.S. University of Peradeniya
1. Molecular mechanisms underlying the manifestation of symptoms in schizophrenia.
2. Neurobiology of autism.
Molecular mechanisms underlying the manifestation of symptoms in schizophrenia:
This line of research involves studying acute and chronic changes in the levels of phosphoproteins, signalling intermediates, transcription factors and target gene expression in key areas in the brain following administration of antipsychotic drugs and psychotropic drugs in animals, and studying molecular changes in animal models of schizophrenia. A number of molecular biological, neuroanatomical and behavioural methods in combination with intracerebral administration of drugs/blockers/siRNA are employed in awake, behaving animals. Expected results may further our understanding of molecular mechanisms underlying schizophrenic symptoms and may point to potential novel therapeutic targets.
Collaborator: Dr. W.J. Rushlow, Department of Psychiatry
Nicolson, R., Devito, T.J., Vidal, C.N., Sui, Y., Hayashi, K.M., Drost, D.J., Williamson, P.C., Rajakumar, N., Toga, A.W. and Thompson, P.M. (2006) Detection and mapping of hippocampal abnormalities in autism. Psychiatry Res. 2006 Oct 20; [Epub ahead of print].
Vidal, C.N., Nicolson, R., DeVito, T.J., Hayashi, K.M., Geaga, J.A., Drost, D.J., Williamson, P.C., Rajakumar, N., Sui, Y., Dutton, R.A., Toga. A.W. and Thompson, P.M. (2006) Mapping corpus callosum deficits in autism: an index of aberrant cortical connectivity. Biol Psychiatry. Aug 1; 60(3): 218-25.
Hendry, J., DeVito, T., Gelman, N., Densmore, M., Rajakumar, N., Pavlosky, W., Williamson, P.C., Thompson, P.M., Drost, D.J. and Nicolson, R. (2006) White matter abnormalities in autism detected through transverse relaxation time imaging. Neuroimage. 2006 Feb 15; 29(4): 1049-57.